PMID: 9553732Apr 29, 1998Paper

Long-term effects of postnatal manipulation on emotionality are prevented by maternal anxiolytic treatment in mice

Developmental Psychobiology
F R D'AmatoC Orsini

Abstract

This study investigated the role of maternal behavior on the long-term effects of postnatal manipulation (15 min of daily separation from the dam and exposure to clean bedding from Day 1 to Day 14 of postnatal life) on emotionality in the mouse. Mothers were treated with an antianxiety agent (Chlordiazepoxide: 5 mg/kg), daily upon removal of the litter from the nest. Emotionality in adult offspring was tested in the elevated plus maze. Mice manipulated during postnatal development were more explorative and less anxious than unhandled mice, but this effect was not observable in the offspring of Chlordiazepoxide-treated dams. No effect of maternal Chlordiazepoxide was observed in unhandled offspring. The pharmacological treatment of the mother did not affect either pups' ultrasonic calling during separation, or maternal behavior far apart from the daily manipulation sessions. By contrast, Chlordiazepoxide-treated dams were less responsive toward pups upon reunion following daily separation. This alteration of dams' behavior was not related to alterations in the amount of ultrasonic calls emitted by pups during reunion. Finally, when dams were daily injected with Chlordiazepoxide far apart from pups' removal, the pharmacological t...Continue Reading

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Citations

Jul 6, 2000·Pharmacology, Biochemistry, and Behavior·A FerreiraA Fernández-Guasti
Oct 28, 1999·Brain Research. Developmental Brain Research·F R D'AmatoF Pavone
Mar 2, 2006·Genes, Brain, and Behavior·V CarolaC Gross
Sep 11, 2009·Genes, Brain, and Behavior·C ZanettiniF R D'Amato
Mar 16, 2007·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Arie Kaffman, Michael J Meaney
Dec 17, 2009·Journal of Neurochemistry·Kelly J SkilbeckTina Hinton
Sep 5, 2006·Neuroscience and Biobehavioral Reviews·Rachel A Millstein, Andrew Holmes
May 11, 2013·Psychoneuroendocrinology·Eva M MarcoGiovanni Laviola
Jul 27, 2011·Hormones and Behavior·Rebecca S HeimingNorbert Sachser
Aug 12, 2000·Stress : the International Journal on the Biology of Stress·A S González JatuffE L Rodríguez Echandía
Aug 31, 2017·Scientific Reports·Aswin HariHsiao-Huei Chen

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