Long-term effects of prepubertal testicular vessel ligation on testicular function in the rat

The Journal of Urology
J A PascualJ Rajfer

Abstract

To determine the effects of unilateral testicular vein and artery ligation in the immature rat on the function and final location of the testis at adulthood, 10-day-old male rats underwent either a sham operation or unilateral ligation of these vessels of the still undescended testis. Testicular location, blood flow, size and histology as well as ventral prostate weights were measured 50 days later at adulthood. At age 60 days, it was determined that all testes were descended into the scrotum, and there were no differences in testis and ventral prostate weights, intratesticular sperm counts and mean seminiferous tubular area between the control and sham operated animals. However, there was an 18% reduction in testicular blood flow (ml. per 100 gm. per minute +/- standard error of mean) in the operated animals when compared to the sham (20.43 +/- 1.10 versus 16.69 +/- 0.74, p less than 0.02). These data indicate that although there is a slight but significant reduction in testicular blood flow at adulthood when the testicular artery and vein are ligated early in life, this diminution is not sufficient to alter the ultimate location, testicular weight and spermatogenic function of the testis. This would suggest that after ligatio...Continue Reading

References

Jan 1, 1977·The Journal of Urology·J F Redman
Nov 1, 1977·Acta Physiologica Scandinavica·J E Damber, P O Janson
Aug 1, 1989·The Journal of Urology·J A PascualJ Rajfer
Jun 1, 1966·Circulation Research·B P SetchellG D Thorburn
Mar 1, 1980·The Journal of Urology·D C Martin, A H Salibian
Dec 1, 1980·The Journal of Urology·S J Silber, R Cohen

Citations

Jun 1, 1996·Scandinavian Journal of Urology and Nephrology·M LeinS Loening
Feb 3, 2006·Scandinavian Journal of Urology and Nephrology·Omer YilmazCan Taneli

Related Concepts

Metazoa
Collateral Circulation
Ligature
Prostate
August Rats
Regional Blood Flow
Seminal Vesicles
Seminiferous Tubule Structure
Sexual Maturation
Finding of Sperm Number

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