Long-term effects of ranibizumab treatment delay in neovascular age-related macular degeneration.

Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie
Philipp S MuetherSascha Fauser

Abstract

Intravitreal injections of ranibizumab are the standard of care for neovascular age-related macular degeneration (AMD). In clinical trials, comparable efficacy has been shown for either monthly injections or as needed injections upon monthly controls. Unlike in trial settings, treatment in clinical routine is often delayed by complex approval procedures of health insurance and limited short-term surgical capacities. Eighty-nine patients with neovascular AMD were followed for 12 months. Early treatment diabetic retinopathy study (ETDRS) visual acuity (VA), Radner reading VA and spectral domain optical coherence tomography were performed monthly, with additional fluorescein angiography if needed. After an initial loading phase of three consecutive monthly intravitreal injections with ranibizumab, re-injections were performed when recurrent activity of choroidal neovascularization (CNV) was detected. After an initial increase to a value of +5.0 ± 11.87 ETDRS letters from baseline, VA constantly decreased over 12 months to a value of -0.66 ± 16.82 ETDRS letters below baseline. Central retinal thickness (CRT) decreased from a value of 438.1 ± 191.4 μm at baseline to a value of 289.9 ± 138.6 μm after initial therapy and stabilized at...Continue Reading

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Citations

Jul 19, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Katharina M DroegeSascha Fauser
Oct 23, 2012·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Katharina M DroegeSascha Fauser
Jan 24, 2014·Clinical Interventions in Aging·Handan CananGürsel Yılmaz
Dec 24, 2013·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Florian M HeussenBert Müller
Apr 12, 2014·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Tae Gon LeeJong Woo Kim
Feb 16, 2016·Clinical & Experimental Optometry : Journal of the Australian Optometrical Association·Jae Hui KimChul Gu Kim
Dec 19, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Joachim WachtlinUNKNOWN BRIDGE investigators
Jun 16, 2015·Acta Ophthalmologica·Annette RasmussenMichael Larsen
Feb 15, 2015·The British Journal of Ophthalmology·Aaron Y LeeUNKNOWN UK AMD EMR Users Group
Oct 19, 2016·Archivos de la Sociedad Española de Oftalmología·R Gallego-PinazoL Monclús
Feb 19, 2016·The British Journal of Ophthalmology·Sascha Fauser, Philipp S Muether
Nov 25, 2016·The British Journal of Ophthalmology·Wolfgang RadnerGabriela Diendorfer
Feb 6, 2018·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Justus G GarwegIsabel B Pfister
Nov 16, 2017·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M W M WintergerstR P Finger
Nov 13, 2019·Vestnik oftalmologii·M V BudzinskayaS G Toropygin
Aug 14, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Joachim WachtlinCarsten Framme
Sep 30, 2020·Journal of Telemedicine and Telecare·Joel MintzKunyong Xu
May 24, 2018·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·S WasselR Hoerster
Jan 16, 2016·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Stacy Hu, Steven Koevary
Nov 20, 2019·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Jae Hui KimJong Woo Kim
Apr 16, 2017·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·W Radner
Feb 22, 2021·Vestnik oftalmologii·R R FayzrakhmanovE O Shatalova
Aug 23, 2021·International Ophthalmology·Daniela ClaessensRohan Bir Singh
Oct 12, 2018·Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde·Vasilena SitnilskaSascha Fauser

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