PMID: 2506607Jan 1, 1989Paper

Long-term effects of switching to cigarettes with lower tar and nicotine yields

Psychopharmacology
A R GuyattG Cumming

Abstract

On switching to cigarettes with lower tar and nicotine yields, most individuals smoke more intensively, but it is not clear if this effect persists over a long period. Smoking behaviour was monitored in 10 male and 18 female volunteers at five monthly visits, smoking commercially available cigarettes (tar yield greater than 10 mg), then for six more visits at 6-week intervals after switching (mean reduction of 5.9 mg tar and 0.45 mg nicotine). Puffing behaviour was monitored with a flow sensing holder, and measurements were made before and after smoking of plasma cotinine, carboxyhaemglobin and alveolar carbon monoxide. After switching, cotinine levels only fell 40% of that predicted from the fall in nicotine yields, and there were no systematic trends for the rest of the study. Puff volumes rose (reflecting perhaps the reduced draw resistance of the lower yield cigarettes), and remained higher thereafter. The number of puffs per cigarette appeared to rise on switching, but then decreased again. In conclusion, most effects of switching to lower yield cigarettes appeared to persist for at least 36 weeks, suggesting that the strategy of reducing exposure to cigarette smoke by lowering tar and nicotine yields may be of limited value.

References

Sep 1, 1978·The British Journal of Addiction to Alcohol and Other Drugs·J H JaffeT Kaplan
Oct 1, 1978·Clinical Pharmacology and Therapeutics·S R SuttonM A Russell
Jan 1, 1977·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·O Siggaard-Andersen
Jun 12, 1976·British Medical Journal·S Freedman, C M Fletcher
Aug 1, 1985·Clinical Physics and Physiological Measurement : an Official Journal of the Hospital Physicists' Association, Deutsche Gesellschaft Für Medizinische Physik and the European Federation of Organisations for Medical Physics·G WoodmanS W Clarke
Sep 1, 1984·Clinical Pharmacokinetics·T D DarbyJ M van Rossum
Nov 1, 1983·Clinical Pharmacology and Therapeutics·N L BenowitzA L Osman
Mar 1, 1983·Psychological Bulletin·M J McMorrow, R M Foxx
Jul 21, 1983·The New England Journal of Medicine·N L BenowitzA L Osman
Jul 1, 1961·Journal of Applied Physiology·J A NADEL, J H COMROE

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Citations

Mar 20, 2012·Psychopharmacology·David A MacqueenDavid J Drobes
Sep 1, 1991·Pharmacology, Biochemistry, and Behavior·S KolonenM M Airaksinen
Jun 1, 1992·Pharmacology, Biochemistry, and Behavior·S KolonenM M Airaksinen
Jan 1, 1994·Pharmacology, Biochemistry, and Behavior·A JacoberK Bättig
Sep 1, 1995·Pharmacology, Biochemistry, and Behavior·J HeeB Festy
Jul 14, 1994·The New England Journal of Medicine·N L Benowitz, J E Henningfield
Jan 1, 1991·The Journal of Psychology·J B Murray
Aug 15, 2013·Nicotine & Tobacco Research : Official Journal of the Society for Research on Nicotine and Tobacco·Melissa D BlankThomas Eissenberg
Jul 1, 1995·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·G AnderssonM Curvall
Dec 5, 2009·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Dorothy K HatsukamiPeter G Shields
Dec 18, 2013·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Chiang-Ming ChenJwo-Leun Lee
Aug 16, 2005·Behavior Research Methods·Alan ShihadehSima Azar
Sep 28, 1999·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·C K HaddockH Lando
Nov 5, 2005·Risk Analysis : an Official Publication of the Society for Risk Analysis·Sajjad Ahmad, John Billimek
Mar 18, 2015·Regulatory Toxicology and Pharmacology : RTP·Anthony CunninghamKrishna Prasad
Oct 4, 2014·Regulatory Toxicology and Pharmacology : RTP·Gerhard Scherer, Peter N Lee
Feb 28, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Tracy T SmithMatthew J Carpenter
May 11, 2012·Central European Journal of Public Health·Maciej Ł GoniewiczAndrzej Sobczak

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