Long-term effects of treatment with nasal continuous positive airway pressure on lung function in patients with overlap syndrome

Sleep & Breathing = Schlaf & Atmung
Javier de MiguelJosé L Alvarez-Sala

Abstract

We assessed the effects of chronic nasal continuous positive airway pressure (CPAP) therapy on lung function in a series of unselected patients with overlap syndrome, and we determined whether there were differences in the response induced by CPAP between hypercapnic (PaCO2 > or =45 mm Hg) and eucapnic patients with overlap syndrome. The study population included 55 unselected patients (48 men, mean age of 58.5 +/- 10.5 years) with a concurrent diagnosis of chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea-hypopnea syndrome (OSAHS) who had been referred to the Department of Pulmonology of our hospital over 2 consecutive years and in whom work-up studies resulted in the prescription of nasal CPAP therapy. An apnea-hypopnea index (AHI) greater than or equal to 10 in the cardiorespiratory polygraphy was required for the diagnosis of OSAHS. A forced expiratory volume in one second (FEV1) less than 80% and FEV1-forced vital capacity (FVC) ratio less than 70% of the reference values were required for the diagnosis of COPD. Control lung function studies and arterial blood gas measurements were performed at 6 and 18 months of CPAP therapy. These patients with overlap syndrome accounted for 28.5% of all patients w...Continue Reading

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Citations

Jan 8, 2004·Sleep & Breathing = Schlaf & Atmung·Victor Hoffstein, Zoe Oliver
Nov 2, 2013·Expert Review of Respiratory Medicine·Romina Wahab, Robert C Basner
Mar 29, 2014·Expert Review of Medical Devices·Meghna P MansukhaniTimothy I Morgenthaler
Dec 7, 2006·COPD·Simrit Bhullar, Barbara Phillips
Dec 14, 2010·Archivos de bronconeumología·Joaquín Durán-CantollaAinhoa Alvarez Ruiz-Larrinaga
Jun 10, 2008·Critical Care Clinics·David Hiestand, Barbara Phillips
Mar 17, 2004·Current Opinion in Pulmonary Medicine·Kesavan Kutty
Nov 11, 2010·Acta Oto-laryngologica·Kiminori SatoTadashi Nakashima
Aug 23, 2019·The Clinical Respiratory Journal·Philippe Jaoude, Ali A El-Solh
Jun 26, 2021·Journal of Clinical Sleep Medicine : JCSM : Official Publication of the American Academy of Sleep Medicine·Yizhong ZhengAmanda Piper
Dec 31, 2021·Pediatric Pulmonology·Aarti ShakkottaiRonald D Chervin

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