Abstract
We evaluated sequelae to early exposure of male rabbits to drinking water containing chemicals typical of ground water near hazardous waste sites. The mixture (p.p.m. at 1x) was 7.75 arsenic, 1.75 chromium, 9.25 lead, 12.5 benzene, 3.75 chloroform, 8.5 phenol and 9.5 trichloroethylene. Dutch-Belted does received mixture at 0x (deionized water; control), 1x or 3x as drinking water from day 20 pregnancy through weaning. Exposure of individual males (7-9/treatment) continued until 15 weeks (adolescence); then, all males received deionized water. At 57-61 weeks of age, ejaculatory capability and seminal, testicular, epididymal and endocrine characteristics were evaluated. At 10 opportunities with a female teaser, all seven control males ejaculated every time, but 12 of the 17 treated males failed to express interest, achieve erection and/or ejaculate on one to five occasions; four of the 12 accomplished ejaculation with a second male teaser. Total spermatozoa/ejaculate and daily sperm production were unaffected. However, treatment caused (P < 0.03) acrosomal dysgenesis and nuclear malformations. Baseline serum concentrations of LH were lower, but with borderline significance (P = 0.05). Testosterone secretion after exogenous human ...Continue Reading
References
Nov 1, 1975·Endocrinology·K J CattJ D Wilson
Oct 1, 1977·Endocrinology·T M Nett, T E Adams
Feb 1, 1976·The American Journal of Anatomy·B GondosD A Goldstein
Jul 17, 1992·Science·A L BurnettS H Snyder
Sep 12, 1992·BMJ : British Medical Journal·E CarlsenN E Skakkebaek
Oct 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R S YangR K Harris
Oct 1, 1989·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R E ChapinR S Yang
Aug 1, 1988·Biology of Reproduction·L D RussellA W Vogl
Jul 1, 1987·Domestic Animal Endocrinology·R L MatteriH Papkoff
Jan 1, 1986·Tissue & Cell·L D RussellA W Vogl
Dec 1, 1986·Environmental Health Perspectives·R P Amann
Apr 1, 1973·The American Journal of Anatomy·B GondosL A Conner
Jan 1, 1974·Journal of Dairy Science·R P AmannJ K Voglmayr
Jul 1, 1974·Journal of Reproduction and Fertility·W E BerndtsonT M Nett
Mar 11, 1974·Zeitschrift für Zellforschung und mikroskopische Anatomie·P BjerregaardT Reumert
Jan 1, 1969·Journal of Animal Science·R P Amann, J T Lambiase
Oct 1, 1967·Journal of Reproduction and Fertility·R P Amann, J T Lambiase
Jan 1, 1982·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R P Amann
Apr 1, 1995·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·J J HeindelR S Yang
Jul 3, 1995·Proceedings of the National Academy of Sciences of the United States of America·E M RinchikM A Handel
Oct 1, 1993·Environmental Health Perspectives·T ColbornA M Soto
May 29, 1993·Lancet·R M Sharpe, N E Skakkebaek
Aug 1, 1996·Environmental Health Perspectives·J ToppariN E Skakkebaek
Mar 1, 1997·Reproductive Toxicology·A J WyrobekD Evenson
Jan 1, 1997·Reproductive Toxicology·R E LinderJ D Suarez
Jun 17, 1998·Reproductive Toxicology·W J MoormanS M Schrader
Feb 18, 1999·JAMA : the Journal of the American Medical Association·E O LaumannR C Rosen
Feb 23, 1999·Advances in Experimental Medicine and Biology·N E Skakkebaek
Feb 3, 2000·Human Reproduction·A G AndersenN E Skakkebaek
Jun 14, 2000·Animal Reproduction Science·D N Veeramachaneni
Dec 2, 2000·Toxicological Sciences : an Official Journal of the Society of Toxicology·L E GrayL Parks
Jun 1, 1964·Journal of Reproduction and Fertility·P J BREDDERMANA M YASSEN
Citations
Jan 23, 2004·Biology of Reproduction·Shelley Brown DuTeauxMarion G Miller
Jul 5, 2006·Environmental Health Perspectives·Gwynne Lyons
Apr 6, 2006·Reproduction : the Official Journal of the Society for the Study of Fertility·D N R VeeramachaneniK-Y F Pau
Jan 16, 2014·Environmental Monitoring and Assessment·Vibudh P KesariParimal K Khan
Dec 25, 2007·Animal Reproduction Science·D N Rao Veeramachaneni
Nov 30, 2006·The Veterinary Clinics of North America. Equine Practice·D N Rao VeeramachaneniHeywood R Sawyer
Dec 17, 2008·International Journal of Andrology·Nader SalamaHiro-omi Kanayama
Jun 3, 2004·The Science of the Total Environment·Gabriella Tamasi, Renzo Cini
Mar 3, 2006·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Julio RubioGustavo F Gonzales
Nov 19, 2005·Reproductive Toxicology·E Sidney HunterNeil Chernoff
Jul 12, 2014·Hormones and Behavior·Kausalya Shenoy
Jan 3, 2015·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Malgorzata Kotula-BalakBarbara Bilinska
Jan 19, 2012·Toxicologic Pathology·D N Rao Veeramachaneni
Sep 25, 2016·Environmental Science and Pollution Research International·Tanapon PhenratSiriwan Wichai
May 2, 2003·Biology of Reproduction·Shelley Brown DuTeauxMarion G Miller
Nov 2, 2007·Environmental and Molecular Mutagenesis·Jane C CaldwellMarina V Evans
Jan 22, 2011·Pest Management Science·Muhammad FarooqKadambot H M Siddique
May 11, 2018·DNA and Cell Biology·Juan Ramos-TreviñoMartha P Nava-Hernández
Apr 15, 2011·Human & Experimental Toxicology·Mónica FerreiraMaria de Lourdes Pereira
Aug 30, 2019·Biological Trace Element Research·B Chaithra Shivabasavaiah
Aug 6, 2021·Toxicology·Felipe Couto-SantosMariana Machado-Neves
Apr 14, 2009·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Sheeba KhanA N K Yusufi