Long-term effects on pressure and electromyography in a rat model of anal sphincter injury

Diseases of the Colon and Rectum
Levilester SalcedoMassarat Zutshi

Abstract

The goal of this research was to study the chronic effects of pudendal nerve transection and sphincterotomy on the anal sphincter, because there is no good animal model investigating anal sphincter injury. Clinically, anal sphincter dysfunction impacts a cohort of women who have fecal incontinence; conclusions from the study can benefit research for new effective treatments. Sixty-eight virgin Sprague-Dawley rats were allocated into control (n = 12), sphincterotomy (n = 28), and pudendal nerve transection (n = 28) groups and were evaluated before injury and immediately, 4 days, 14 days, and 28 days after. Anal pressures and electromyography were recorded and statistically compared. The anal sphincter was submitted to histology. : Sphincterotomy data showed anal pressure recovery 14 days after injury and were comparable to controls after 28 days. Pudendal nerve transection showed a significant decrease in anal pressure 4 days after injury (P < .001), and this continued until 28 days after injury (P = .01). Electromyography showed significant loss of activity after nerve transection compared with controls. Twenty-eight days after sphincterotomy and nerve transection, fibrosis and muscle atrophy of the external anal sphincter musc...Continue Reading

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Citations

Dec 14, 2011·Diseases of the Colon and Rectum·K M GriffinJ F X Jones
Nov 9, 2012·Diseases of the Colon and Rectum·Margot S DamaserMassarat Zutshi
Nov 16, 2012·American Journal of Physiology. Renal Physiology·Hai-Hong JiangMargot S Damaser
May 28, 2013·The Journal of Surgical Research·Izumi YamaguchiSusumu Eguchi
Nov 14, 2012·Stem Cell Research·Levilester SalcedoMassarat Zutshi
Apr 12, 2013·Journal of the Korean Surgical Society·Sung-Bum KangJin Ho Lee
Aug 5, 2016·Scientific Reports·Flavio H F GalvãoLuiz Carneiro D'Albuquerque
May 7, 2014·Stem Cells Translational Medicine·Levilester SalcedoMassarat Zutshi
Mar 8, 2017·Diseases of the Colon and Rectum·Li SunMassarat Zutshi
Mar 10, 2018·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Xiaojia LiJingen Lu
Feb 1, 2018·Stem Cells Translational Medicine·Kirsi KuismanenSusanna Miettinen
Aug 7, 2018·World Journal of Stem Cells·Jacobo TrébolDamián García-Olmo
Feb 3, 2018·World Journal of Stem Cells·Jacobo TrébolDamián García-Olmo
Dec 4, 2019·Scientific Reports·Prabhash DadhichKhalil N Bitar
May 10, 2017·Diseases of the Colon and Rectum·Judith EversP Ronan O'Connell

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