Long-term efficacy and safety of intralesional steroid injection plus oral steroid administration in preventing stricture after endoscopic submucosal dissection for esophageal epithelial neoplasms.

Surgical Endoscopy
Yuan ChuMei Dong Xu

Abstract

Endoscopic submucosal dissection (ESD) has been widely accepted as the treatment for early-stage esophageal epithelial neoplasms. However, stricture is a common complication after large-circumference ESD. This retrospective study is conducted to evaluate the efficacy and safety of intralesional steroid injection plus oral steroid administration in preventing esophageal stricture. 70 patients with a mucosal defect extending over more than two-thirds of the circumference after esophageal ESD for epithelial neoplasms were enrolled in this study. Those who received intralesional triamcinolone injection combined with oral prednisolone administration were assigned to the treatment group, while those who were treated without any prophylaxis of esophageal stricture were assigned to the control group. The primary observation result was the frequency of stricture. The secondary observation results were the number of endoscopic balloon dilation (EBD) sessions and rate of complications. Compared with the control group, the frequency of stricture (14.7% 5/34 patients vs. 51.5% 19/36 patients) and number of EBD sessions (mean 0.2 vs. 3.3) were significantly lower in the treatment group. One patient suffered from perforation in the treatment ...Continue Reading

References

Jun 20, 2007·The Surgeon : Journal of the Royal Colleges of Surgeons of Edinburgh and Ireland·M Jalali, A Bayat
Aug 24, 2007·Digestive Diseases and Sciences·Yasuharu SaitoYoshihide Fujiyama
Mar 24, 2016·Endoscopy International Open·Noboru HanaokaHiroyasu Iishi
Apr 14, 2017·BMJ : British Medical Journal·Akbar K WaljeeBrahmajee K Nallamothu

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Citations

Jul 4, 2020·Current Opinion in Gastroenterology·Mary Raina Angeli AbadHaruhiro Inoue
Dec 31, 2020·Journal of Clinical Medicine·Katsunori Matsueda, Ryu Ishihara

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