[Long-term efficacy and side effects of various migraine prophylactics: a retrospective analysis.].

Der Schmerz
G HaagM J Müller

Abstract

Drug therapy for the prevention of migraine attacks is becoming more and attacks is becoming more and more important. The aims of such prophylactic treatment are to reach a lower frequency, shorter duration and milder intensity of migraine attacks, and to reduce the intake of anti-migraine medication, to improve the quality of life and working ability. The question of efficacy and tolerance of established migraine prophylactics [1] has been thoroughly investigated in many studies. So far the question of sustained efficacy after a successful prophylactic treatment completion has not been a research priority, but it is nonetheless of great importance. Researchers at the neurologic scientific research institute of the university of Naples have followed up migraine out-patients after successful prophylactic treatment and observed that prophylactic agents differ not only in their immediate efficacy and safety, but also in long-term efficacy. Therefore, an open pilot study was performed with the prophylactic agents propranolol, flunarizine, pizotifen, DHE retard, methysergide and cyclandelate in the recommended dossages (Tabe 1). The aim of this study was to determine whether the various prophylactic agents available differ in active...Continue Reading

References

Dec 1, 1991·Cephalalgia : an International Journal of Headache·C WöberP Wessely
Jan 1, 1988·Cephalalgia : an International Journal of Headache·J M Martínez-Lage
May 1, 1985·Cephalalgia : an International Journal of Headache·G BonoG Nappi

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