Long-term efficacy of dolutegravir plus lamivudine for maintenance of HIV viral suppression in adults with and without historical resistance to lamivudine: Week 96 results of ART-PRO pilot study.

The Journal of Antimicrobial Chemotherapy
David Rial-CresteloPI16/00837-PI16/00678 study group

Abstract

In the ART-PRO pilot trial there were no virological failures through 48 weeks of treatment with dolutegravir plus lamivudine in suppressed individuals with and without archived lamivudine resistance-associated mutations (RAMs) detected through next-generation sequencing (NGS) but without evidence of lamivudine RAMs in baseline proviral DNA population sequencing. To present 96 week results from ART-PRO. Open-label, single-arm pilot trial. At baseline, all participants switched to dolutegravir plus lamivudine. Participants were excluded if proviral DNA population genotyping detected lamivudine RAMs. To detect resistance minority variants, proviral DNA NGS was retrospectively performed from baseline samples. For this analysis the efficacy endpoint was the proportion of participants with <50 HIV-1 RNA copies/mL at week 96. Safety and tolerability outcomes were incidence of adverse events and treatment discontinuations. Forty-one participants were included, 21 with lamivudine RAMs in historical plasma RNA genotypes. Baseline proviral DNA NGS detected lamivudine RAMs (M184V/I and/or K65R/E/N) above a 5% threshold in 71.4% (15/21) and 15% (3/20) of participants with and without history of lamivudine resistance, respectively. At 96 we...Continue Reading

References

Oct 16, 2004·Expert Review of Anti-infective Therapy·Mark A Wainberg
Jun 29, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Thomas B CampbellDaniel R Kuritzkes
Jan 3, 2019·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Laurent HocquelouxUNKNOWN MONCAY study group

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Citations

Mar 19, 2021·The Journal of Antimicrobial Chemotherapy·Santiago Jiménez de OryUNKNOWN Paediatric Cohort of the Spanish National AIDS Network (CoRISpe and CoRISpe-FARO)
Aug 21, 2021·The Journal of Infectious Diseases·Romain PalichAnne-Geneviève Marcelin

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