Long-term efficacy of drug coated balloons compared with new generation drug-eluting stents for the treatment of de novo coronary artery lesions

Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions
Dimitrios VenetsanosJoakim Alfredsson

Abstract

Studies comparing drug coated balloons (DCB) with new generation drug-eluting stents (nDES) for the treatment of de novo coronary artery lesions are lacking. From 2009 to 2016, DCB or nDES used for treatment of de novo coronary lesions at our institution were included, in total 1,197 DEB and 6,458 nDES. We evaluated target lesions restenosis (TLR) and definite target lesion thrombosis (TLT). Propensity score modeling were utilized to study adjusted associations between treatment and outcomes. Median follow-up was 901days. DCB patients were older, with higher cardiovascular risk profile. Bailout stenting after DCB was performed in 8% of lesions. The cumulative rate of TLR and TLT was 7.0 vs. 4.9% and 0.2 vs. 0.8% for DCB vs. nDES, respectively. Before adjustment, DCB was associated with a higher risk of TLR [hazard ratio (HR) 1.44; 95% confidence interval (CI) 1.07-1.94] and a non-significantly lower risk of TLT (HR 0.30; 95% CI 0.07-1.24), compared to nDES. In the propensity matched population consisted of 1,197 DCB and 1,197 nDES, treatment with DCB was associated with similar risk for TLR (adjusted HR 1.05; 95% CI 0.72-1.53) but significantly lower risk for TLT (adjusted HR 0.18; 95% CI 0.04-0.82) compared to nDES. Treatment ...Continue Reading

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Citations

Nov 23, 2018·International Heart Journal·Takehiro HashikataMasao Yamasaki
Dec 24, 2019·Catheterization and Cardiovascular Interventions : Official Journal of the Society for Cardiac Angiography & Interventions·Luiz F YbarraStéphane Rinfret
Jan 11, 2020·Expert Opinion on Drug Delivery·Thomas NestelbergerRaban Jeger
Dec 24, 2019·Interventional Cardiology·Thomas Nestelberger, Raban Jeger
Oct 30, 2019·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Bruno SchellerAnne Bärisch
Jan 30, 2020·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Gregor FahrniUNKNOWN BASKET-SMALL 2 Investigators
Apr 1, 2019·The International Journal of Cardiovascular Imaging·Yi LiuLing Tao
Sep 28, 2020·International Journal of Cardiology·D VenetsanosJ Alfredsson
Jan 16, 2021·Journal of Interventional Cardiology·Katsumi UenoMasayasu Esaki
Mar 7, 2020·Journal of the American College of Cardiology·Bruno SchellerFelix Mahfoud
Feb 18, 2020·JACC. Cardiovascular Interventions·Angelo SilverioGiovanna Sarno
Oct 15, 2021·Current Cardiology Reports·Ketina Arslani, Raban Jeger

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