Long-term efficacy of glycerine-processed amniotic membrane transplantation in patients with corneal ulcer

Acta Ophthalmologica
Constantin E UhligAnne F Alex

Abstract

The aim of this study was to determine the long-term treatment efficacy of glycerine-preserved human amniotic membrane transplantation in patients suffering from corneal ulcers. This was a retrospective, non-controlled, monocentric analysis. Included were patients with corneal ulcers that were non-responsive to ointment or contact lenses and had been treated by amniotic membrane transplantation with either the overlay or sandwich procedure. Analysis parameters were visual acuity before and following treatment, recurrence rate and subjective comfort at the last follow-up. Of the 371 amniotic membrane transplantations that were conducted, 135 surgical treatments in 108 patients (51.9% male, 48.1% female; mean age 63.7 years) met the inclusion criteria. In total, 99 overlay and 36 multilayer amniotic membrane transplantations were performed. The follow-up period was 47.5 ± 66.7 weeks (mean ± SD). The recurrence rate at the last follow-up was 47.8% with overlay membranes and 51.8% with the sandwich technique. There was no significant change in best-corrected visual acuity following treatment with overlays (p = 0.219) or sandwich procedure (p = 0.703). At the last follow-up, 72.1% (overlay) and 78.3% (sandwich) of the patients repor...Continue Reading

References

May 1, 1991·Placenta·Y P TalmiY Zohar
Mar 1, 1997·American Journal of Ophthalmology·S H Lee, S C Tseng
Dec 24, 1997·American Journal of Ophthalmology·S C TsengS H Lee
Aug 6, 1999·The British Journal of Ophthalmology·A Azuara-BlancoH S Dua
Oct 26, 1999·Archives of Ophthalmology·R T PiresD T Tan
Dec 3, 1999·Klinika oczna·J Markuszewska, P Krzyzanowska
Mar 29, 2000·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·D Meller, S C Tseng
Mar 29, 2000·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·T Reinhard, R Sundmacher
Jul 25, 2000·The British Journal of Ophthalmology·H J ChenS C Tseng
Sep 27, 2000·American Journal of Ophthalmology·M S SridharG N Rao
Feb 13, 2001·European Journal of Obstetrics, Gynecology, and Reproductive Biology·N KjaergaardH Madsen
Mar 10, 2001·American Journal of Ophthalmology·K HanadaK Tsubota
Apr 24, 2001·The British Journal of Ophthalmology·D F AndersonS C Tseng
Oct 12, 2001·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·F E Kruse, D Meller
Mar 27, 2002·The British Journal of Ophthalmology·D MellerS C G Tseng
Mar 5, 2003·Advances in Experimental Medicine and Biology·Shigeru KinoshitaKohji Nishida
Nov 25, 2003·Eye·S BoniniA Lambiase
May 27, 2004·Investigative Ophthalmology & Visual Science·Chunkui ShaoJian-xing Ma
Jul 17, 2004·Cornea·M Teresa Rodríguez-AresFrancisco Gude
Jul 13, 2005·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·A SolomonF Levi-Schaffer
Aug 20, 2005·Experimental Eye Research·Wei LiScheffer C G Tseng
Jul 4, 2006·American Journal of Ophthalmology·Constantin E UhligMarkus Groppe
Nov 22, 2007·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·B Seitz
Jul 1, 1947·The British Journal of Ophthalmology·A SorsbyH Reed

❮ Previous
Next ❯

Citations

Jan 12, 2017·Tissue Engineering. Part a·Emma Muiños-LópezSilvia María Díaz-Prado
Oct 22, 2019·Cornea·Kaspar SchuerchChristoph Tappeiner
Jun 10, 2020·International Journal of Molecular Sciences·Olena PogozhykhConstança Figueiredo
Oct 3, 2017·Neural Regeneration Research·Marta Sacchetti, Alessandro Lambiase
Apr 21, 2016·Current Opinion in Ophthalmology·Sonal Tuli, Matthew Gray

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.