Long-term efficacy of interleukin-1 receptor antagonist (anakinra) in corticosteroid-dependent and colchicine-resistant recurrent pericarditis

The Journal of Pediatrics
Martina FinettiMarco Gattorno


To evaluate the long-term response and safety of interleukin-1 receptor antagonist (anakinra) in recurrent pericarditis. Fifteen patients (12 children, 3 adults) were enrolled in a multicenter retrospective study. All the patients were corticosteroid-dependent and 14 had received colchicine. Anakinra was given at 1-2 mg/kg/d. The primary outcome of the study was a reduction of at least 70% of disease flares after anakinra treatment compared with the pretreatment period. Secondary outcomes were: (1) number of complete or partial responders to anakinra and time for complete response; (2) number of patients who discontinued other ongoing treatments (non-steroidal anti-inflammatory drugs, corticosteroid, colchicine) and time needed for discontinuation; (3) number of relapses during continuous anakinra treatment; and (4) number of relapses during anakinra tapering or discontinuation. All patients treated had a complete response within a few days and were able to rapidly withdraw concomitant treatments, including corticosteroids. During daily treatment, no patient had a relapse of the disease; 14 patients started tapering and 6 of them experienced a relapse, with a prompt response after anakinra reintroduction. Overall, after a media...Continue Reading


Oct 20, 2005·Rheumatology·A SimonUNKNOWN International HIDS Study Group
Sep 1, 2006·PLoS Medicine·Dennis McGonagle, Michael F McDermott
Jan 24, 2008·Nature Clinical Practice. Cardiovascular Medicine·Massimo ImazioYehuda Adler
Mar 24, 2009·Annual Review of Immunology·Seth L MastersDaniel L Kastner
Feb 24, 2010·Circulation·Massimo ImazioYehuda Adler
May 12, 2010·Proceedings of the National Academy of Sciences of the United States of America·Anna SimonRichard M Siegel
May 22, 2010·International Journal of Clinical Practice·M ImazioY Adler
Jun 1, 2010·Mayo Clinic Proceedings·Masud H KhandakerJae K Oh
Aug 30, 2011·Annals of Internal Medicine·Massimo ImazioUNKNOWN CORP (COlchicine for Recurrent Pericarditis) Investigators
Feb 9, 2012·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Luca CantariniMassimo Imazio
Jun 19, 2012·International Journal of Cardiology·Dimitrios VassilopoulosDimitrios Pectasides
Jul 26, 2012·Nature Reviews. Immunology·Heiyoung ParkRichard M Siegel
Aug 14, 2012·Autoimmunity Reviews·Silvia MaestroniAntonio Brucato
Oct 12, 2012·Pediatric Cardiology·Alessandra ScardapaneLuciana Breda
Feb 13, 2013·Arthritis and Rheumatism·Marco Gattorno, Alberto Martini
Feb 14, 2013·Clinical Cardiology·Gal MarkelYehuda Adler
Mar 7, 2013·Pediatric Cardiology·Marisol Camacho-Lovillo, Ana Méndez-Santos
Apr 24, 2013·Circulation·Leonard S Lilly
Apr 24, 2013·American Journal of Medical Genetics. Part a·Paolo PiccoAlberto Martini
Aug 24, 2013·Annals of the Rheumatic Diseases·H J LachmannUNKNOWN Paediatric Rheumatology International Trials Organisation (PRINTO), the EUROTRAPS and the Eurofever Project
Sep 3, 2013·The New England Journal of Medicine·Massimo ImazioUNKNOWN ICAP Investigators

❮ Previous
Next ❯


Sep 23, 2014·Revista Española De Cardiología·Lovely ChhabraDavid H Spodick
Jan 9, 2016·The American Journal of Cardiology·Dor LotanYehuda Adler
Dec 23, 2015·Expert Review of Cardiovascular Therapy·Syed Wamique YusufPatrick T O'Gara
Apr 10, 2015·Heart·Massimo Imazio, Fiorenzo Gaita
Dec 3, 2014·International Journal of Cardiology·Claire MassardierMartin Soubrier
Mar 5, 2016·Cardiology Research and Practice·Shankar BaskarAndrew Zeft
Mar 21, 2016·Current Cardiology Reports·James GentryChristine L Jellis
Mar 24, 2016·Current Cardiology Reports·Alexander FardmanYehuda Adler
Aug 19, 2015·The American Journal of Cardiology·Sonia JainEric L Matteson
Dec 3, 2014·Trends in Cardiovascular Medicine·Massimo Imazio
Dec 18, 2014·The New England Journal of Medicine·Martin M LeWinter
Oct 14, 2014·Autoimmunity Reviews·Luca CantariniDonato Rigante
Oct 12, 2016·Progress in Cardiovascular Diseases·Massimo ImazioFiorenzo Gaita
Jan 13, 2017·Pharmacotherapy·Nicholas C SchwierMarie L Davies
Dec 19, 2016·Progress in Cardiovascular Diseases·Craig R Asher, Allan L Klein
Dec 14, 2016·Progress in Cardiovascular Diseases·Niraj S DoctorItzhak Kronzon
Jun 22, 2017·European Heart Journal. Cardiovascular Pharmacotherapy·Leo F BuckleyAntonio Abbate
Jul 2, 2014·Nature Reviews. Cardiology·Lovely ChhabraDavid H Spodick
Aug 15, 2018·Expert Review of Cardiovascular Therapy·Alessandro Galluzzo, Massimo Imazio
Nov 13, 2018·Journal of Cellular Physiology·Aldo Bonaventura, Fabrizio Montecucco
Jul 29, 2016·Journal of Cardiovascular Medicine·Massimo ImazioAlberto Martini
Jan 26, 2016·Journal of Cardiovascular Medicine·Massimo ImazioYehuda Adler
Jun 9, 2020·Expert Opinion on Pharmacotherapy·Paramarjan Piranavan, Andras Perl
Jan 3, 2019·Pediatrics in Review·Hari TunuguntlaSusan W Denfield
Apr 11, 2018·Internal and Emergency Medicine·Antonio BrucatoDomenico Prisco
Nov 5, 2019·Frontiers in Pediatrics·Enrico TombettiRolando Cimaz
Jun 18, 2020·Pediatric Rheumatology Online Journal·Sara SignaMarco Gattorno
Jun 16, 2018·Current Cardiology Reports·Giacomo EmmiAntonio Brucato
Jun 21, 2020·Current Cardiology Reports·Enrico TombettiCarla Carnovale
Apr 9, 2020·Journal of Cardiovascular Pharmacology·Eduardo Thadeu de Oliveira CorreiaEvandro Tinoco Mesquita
Jan 1, 2018·Current Otorhinolaryngology Reports·Charles A Dinarello
Mar 13, 2021·Frontiers in Pharmacology·Hana MalcovaRudolf Horvath
Aug 2, 2020·Jornal de pediatria·Stasa KrasicVladislav Vukomanovic
Apr 9, 2019·Autoimmunity Reviews·Nathan Peiffer-SmadjaPatrice Cacoub
May 8, 2020·Trends in Cardiovascular Medicine·Giuseppe LopalcoFlorenzo Iannone
Jul 16, 2021·Journal of Community Hospital Internal Medicine Perspectives·Vinay Kumar ThallapallyJoseph Nahas

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adult-Onset Still's Disease

Adult-onset Still's disease (AOSD) is a form of Still's disease, a rare systemic autoinflammatory disease characterized by the classic triad of persistent high spiking fevers, joint pain, and a distinctive salmon-colored bumpy rash. Discover the latest research on AOSD here.