Long-term etanercept retention patterns and factors associated with treatment discontinuation: a retrospective cohort study using Canadian claims-level data

Clinical Rheumatology
Majed KhraishiHeather Jones

Abstract

To examine 12-month retention rates over 6 years of etanercept patients in Canada, and to identify factors associated with treatment discontinuation. A retrospective cohort study was conducted using longitudinal prescription drug claims data from IQVIA Private Drug Plan database (PDP), Ontario Public Drug Plan database (OPDP), and Régie de l'assurance maladie du Québec database (RAMQ). Between 07/2008 and 06/2010, bio-naïve patients who initiated etanercept were identified and followed for 72 months. Twelve-month retention rates were estimated in one-year increments and factors associated with time to discontinuation over the 72-month period were identified using a Cox proportional hazards regression model. The study identified 4528 etanercept patients (61% female, 85% rheumatic diseases, and 15% psoriasis). Twelve-month etanercept retention rates increased significantly for patients following their first year on therapy (p < 0.0001), with 66% of patients retained at year 1 vs. 79, 82, 84, 83, and 79% at years 2, 3, 4, 5, and 6, respectively. 17.1% (n = 771) of patients were retained for the entire 72-month study. Patients with psoriasis were at increased risk (HR 1.199; p < 0.0001); while public drug coverage plan patients (OP...Continue Reading

References

Dec 11, 2002·JAMA : the Journal of the American Medical Association·Heather P McDonaldR Brian Haynes
Apr 11, 2003·Lancet·Mark Lebwohl
Jun 3, 2004·Rheumatic Diseases Clinics of North America·Mark C Genovese, Joel M Kremer
Nov 27, 2007·Nature Clinical Practice. Rheumatology·Samy Suissa, Edeltraut Garbe
May 1, 2009·Arthritis and Rheumatism·Sophie Martin Du PanUNKNOWN Swiss Clinical Quality Management Physicians
Nov 3, 2011·The Journal of Rheumatology. Supplement·Philip JacobsLyn C Guenther
Nov 15, 2011·Expert Opinion on Drug Safety·Todd A KerenskyShiu-chung Au
Apr 3, 2012·The Journal of Rheumatology·Florenzo IannoneUNKNOWN Gruppo Italiano di Studio sulle Early Arthritides (GISEA)
Oct 17, 2013·Alimentary Pharmacology & Therapeutics·K BüschM Neovius

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Citations

Aug 11, 2020·Clinical Rheumatology·Giuseppe ProvenzanoMaria Concetta Miceli
Sep 19, 2020·BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy·Chia-Ling YuChing-Chi Chi

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