Long-term everolimus treatment of patients with pancreatic neuroendocrine tumors

Chemotherapy
Edward M Wolin

Abstract

Based on the significant prolongation of progression-free survival in a randomized phase III trial, RADIANT-3 (RAD001 in Advanced Neuroendocrine Tumors, Third Trial), everolimus has been approved for the management of advanced, progressive pancreatic neuroendocrine tumors (pNET). Here, we describe 15 participants in RADIANT-3 who were treated with everolimus at our study center. We report the long-term survival of a subset of patients. Patients with advanced, progressive pNET were randomly assigned to the everolimus arm of RADIANT-3 or received everolimus as open-label treatment after experiencing progression on placebo or during the unblinded phase. Five patients on everolimus (5-10 mg/day) had stable disease for >43 to >76 months after initiating treatment. Three patients achieved stable disease for 19-25 months, but died of progressive malignancy thereafter. Seven patients had stable disease for ≤11 months after initiating everolimus therapy. Patients with advanced, progressive pNET can obtain long-term benefit from daily oral treatment with everolimus.

Citations

Oct 21, 2016·Endocrine-related Cancer·Simona FallettaMaria Chiara Zatelli
Jul 17, 2018·World Journal of Surgical Oncology·Giuseppe NigriGiovanni Ramacciato

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