Long-term evolution of an untreated primary cutaneous follicle center lymphoma of the scalp

The American Journal of Dermatopathology
Maria Teresa FierroMaria Grazia Bernengo

Abstract

Among primary cutaneous B-cell lymphomas, follicle center lymphomas represent, according to the World Health Organization-European Organisation For Research and Treatment of Cancer classification, a subgroup with a favorable prognosis. We describe the case of a 45-year-old man who presented with large infiltrated tumors and nodules coalescing into a wide ulcerated plaque of the scalp, extending from the frontal to the occipital region. At the vertex, 2 large ulcerations were present, reaching the subcutaneous tissues and the underlying bone structures with osseus infiltration and erosion and consequent meningeal exposure. A left retroauricular lymphadenopathy was also present. Histology and immunohystochemistry diagnosed a relapse of primary cutaneous follicle center lymphoma with multilobated histomorphology and lymph node involvement. The histological picture was unchanged from the first sample of 1989. Due to a refusal to treatment, the lesion progressively grew until now. After 6 courses of chemotherapy (cyclophosphamide, vincristine, liposomal doxorubicin, prednisone-Rituximab), the tumor displayed an impressive complete regression with the persistence of a 4-cm occipital ulceration and underlying bone erosion. The adenopa...Continue Reading

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Citations

Dec 1, 2011·The American Journal of Dermatopathology·Angel Fernandez-Flores
Mar 18, 2011·The British Journal of Dermatology·J KlukR A Carr
Nov 9, 2018·Archives of Pathology & Laboratory Medicine·Stephanie L SkalaAlexandra C Hristov
Jul 4, 2019·International Journal of Dermatology·Eran ShavitAfsaneh Alavi
Mar 25, 2014·The American Journal of Dermatopathology·Werner KempfChristina Mitteldorf
Dec 4, 2019·Journal of Pediatric Gastroenterology and Nutrition·Wael N SayejJeffrey S Hyams
May 18, 2020·Dermatologic Therapy·Magda ZanelliStefano Ascani
Mar 6, 2015·Journal of the History of the Behavioral Sciences·Edmund Ramsden
Aug 21, 2020·American Journal of Hematology·Alexandra C HristovRyan A Wilcox
Jan 25, 2020·Journal of Pediatric Gastroenterology and Nutrition·Wael N SayejJeffrey S Hyams
Sep 2, 2014·Journal of the European Academy of Dermatology and Venereology : JEADV·M MascoloS Staibano

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