Long-term evolution of antigen repertoires among carried meningococci.

Proceedings. Biological Sciences
Caroline O BuckeeKeith A Jolley

Abstract

Most studies of bacterial pathogen populations have been based on isolates collected from individuals with disease, or their contacts, over short time periods. For commensal organisms that occasionally cause disease, such as Neisseria meningitidis, however, the analysis of isolates from long-term asymptomatic carriage is necessary to elucidate their evolution and population structure. Here, we use mathematical models to analyse the structuring and dynamics of three vaccine-candidate antigens among carried meningococcal isolates collected over nearly 30 years in the Czech Republic. The data indicate that stable combinations of antigenic alleles were maintained over this time period despite evidence for high rates of recombination, consistent with theoretical models in which strong immune selection can maintain non-overlapping combinations of antigenic determinants in the presence of recombination. We contrast this antigenic structure with the overlapping but relatively stable combinations of the housekeeping genes observed among the same isolates, and use a novel network approach to visualize these relationships.

References

May 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·J M SmithB G Spratt
Dec 2, 2000·Journal of Clinical Microbiology·K A JolleyM C Maiden
Feb 13, 2002·Proceedings. Biological Sciences·M Gabriela M GomesD James Nokes
Mar 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·John Alroy
Apr 11, 2002·Journal of Mathematical Biology·J R Gog, J Swinton
May 4, 2002·Lancet·Luis JódarDan M Granoff
Dec 14, 2002·Proceedings of the National Academy of Sciences of the United States of America·Julia R Gog, Bryan T Grenfell
Jul 12, 2003·Microbiology·Emily A L ThompsonMartin C J Maiden
Jun 18, 2004·Emerging Infectious Diseases·Joanne E RussellJanet Suker
Jul 13, 2004·Proceedings of the National Academy of Sciences of the United States of America·Caroline O'F BuckeeSunetra Gupta
Apr 6, 2006·The Journal of Infectious Diseases·Lee H HarrisonUNKNOWN Maryland Emerging Infections Program
Aug 1, 2006·International Journal of Medical Microbiology : IJMM·Martin V R WeberUlrich Vogel
Sep 26, 2008·Proceedings of the National Academy of Sciences of the United States of America·Caroline O BuckeeMartin C J Maiden
May 26, 2009·Vaccine·Dominique A Caugant, Martin C J Maiden
May 30, 2009·Vaccine·Lee H HarrisonMary E Ramsay

❮ Previous
Next ❯

Citations

Aug 31, 2011·Proceedings of the National Academy of Sciences of the United States of America·Caroline O BuckeeSunetra Gupta
Jun 27, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Martin C J Maiden
Jun 28, 2013·Clinical and Vaccine Immunology : CVI·Jay LucidarmeRay Borrow
Dec 3, 2010·Journal of Clinical Microbiology·Fadil A BidmosChristopher D Bayliss
Jul 26, 2012·Future Microbiology·Holly B BratcherMartin C J Maiden
Nov 14, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·C ChattT Fowler
Oct 10, 2014·Scientific Reports·Eleanor R WatkinsCaroline O Buckee
May 29, 2015·BMC Bioinformatics·José LourençoSunetra Gupta
Sep 24, 2016·Future Microbiology·Eleanor R WatkinsSunetra Gupta
Jan 24, 2017·Scientific Reports·Eleanor R Watkins, Martin C J Maiden
Nov 28, 2018·Nature Reviews. Immunology·Maria GeorgievaMarc Lipsitch
Aug 11, 2020·Microbial Genomics·Philip H C KremerDiederik van de Beek
Jan 6, 2017·Proceedings of the National Academy of Sciences of the United States of America·Nicholas J CroucherMarc Lipsitch
Feb 17, 2019·Scientific Reports·Katrina J SpensleyJosé Lourenço

❮ Previous
Next ❯

Software Mentioned

e B urst

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.