Long-Term Exercise Protects against Cellular Stresses in Aged Mice

Oxidative Medicine and Cellular Longevity
Irina BelayaShuzo Kumagai

Abstract

The current study examined the effect of aging and long-term wheel-running on the expression of heat shock protein (HSP), redox regulation, and endoplasmic reticulum (ER) stress markers in tibialis anterior (T.A.) and soleus muscle of mice. Male mice were divided into young (Y, 3-month-old), old-sedentary (OS, 24-month-old), and old-exercise (OE, 24-month-old) groups. The OE group started voluntary wheel-running at 3 months and continued until 24 months of age. Aging was associated with a higher thioredoxin-interacting protein (TxNiP) level, lower thioredoxin-1 (TRX-1) to TxNiP ratio-a determinant of redox regulation and increased CHOP, an indicator of ER stress-related apoptosis signaling in both muscles. Notably, GRP78, a key indicator of ER stress, was selectively elevated in T.A. Long-term exercise decreased TxNiP in T.A. and soleus muscles and increased the TRX-1/TxNiP ratio in soleus muscle of aged mice. Inducible HSP70 and constituent HSC70 were upregulated, whereas CHOP was reduced after exercise in soleus muscle. Thus, our data demonstrated that aging induced oxidative stress and activated ER stress-related apoptosis signaling in skeletal muscle, whereas long-term wheel-running improved redox regulation, ER stress adap...Continue Reading

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Citations

Oct 19, 2019·Pflügers Archiv : European journal of physiology·Saber Ghazizadeh DarbandMaryam Majidinia
Feb 23, 2020·Diabetology & Metabolic Syndrome·Jian ShouWei-Hua Xiao
Jul 4, 2019·Current Pharmaceutical Design·Katarina SmilkovMustafa Atalay
May 17, 2019·Oxidative Medicine and Cellular Longevity·Danyang Tian, Jinqi Meng
Oct 13, 2020·Mechanisms of Ageing and Development·Jeremy ThompsonQun Chen

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Methods Mentioned

BETA
protein folding
protein assay
ELISA

Software Mentioned

Odyssey
SPSS

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