Long-term experience with deferasirox (ICL670), a once-daily oral iron chelator, in the treatment of transfusional iron overload

Expert Opinion on Pharmacotherapy
Maria Domenica Cappellini, Ali Taher

Abstract

Chronic iron overload from frequent blood transfusions to treat patients with severe anaemias leads to significant morbidity and mortality. While deferoxamine, the current standard of care, is an effective iron chelator, it requires subcutaneous infusion for 8-12 h/day, 5-7 days/week. This regimen is problematic and impacts significantly on patients' daily life. To evaluate the efficacy and tolerability of deferasirox, a once-daily oral iron chelator. To review the available data reported in peer-reviewed journals (using PubMed) and at medical conferences. Deferasirox is effective in reducing or maintaining iron burden in patients with transfusion-dependent anaemias. As deferasirox is orally administered, the inconvenience of parenteral administration with deferasirox is avoided. Deferasirox improves patient satisfaction and is expected to improve compliance with iron chelation therapy.

References

Sep 1, 1994·The New England Journal of Medicine·G M BrittenhamJ W Harris
Sep 1, 1994·The New England Journal of Medicine·N F OlivieriA R Cohen
Jan 1, 1996·Acta Haematologica·V Gabutti, A Piga
Jul 21, 1998·Annals of the New York Academy of Sciences·C Borgna-PignattiG Verlato
Jul 8, 1999·The New England Journal of Medicine·N F Olivieri
Jul 9, 2002·British Journal of Haematology·Adriana CeciFernando Tricta
Feb 8, 2003·Advances in Experimental Medicine and Biology·Hanspeter NickHans Peter Schnebli
Apr 8, 2003·Current Medicinal Chemistry·Hanspeter NickDaniele Alberti
Feb 28, 2004·Blood·Melody J CunninghamUNKNOWN Thalassemia Clinical Research Network
Nov 25, 2006·Hematology·Alan R Cohen
Dec 6, 2006·Translational Research : the Journal of Laboratory and Clinical Medicine·John C WoodRex Moats
Jan 20, 2007·British Journal of Haematology·Elliott VichinskyUNKNOWN Deferasirox in Sickle Cell Investigators
Jun 26, 2007·Experimental Hematology·Maya Otto-DuesselJohn C Wood
Dec 7, 2007·American Journal of Hematology·Elliott Vichinsky
Jun 24, 2008·The American Journal of Cardiology·Radhakrishnan Ramaraj, Joseph Stephen Alpert

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Citations

Apr 29, 2010·Internal and Emergency Medicine·Clara Camaschella, Paolo Strati
Feb 24, 2010·Indian Journal of Pediatrics·M B Agarwal
Oct 29, 2009·International Journal of Hematology·Vip ViprakasitArchrob Khuhapinant
Oct 1, 2010·Journal of Pediatric Hematology/oncology·Kyung Nam KohJong Jin Seo
Jul 28, 2009·Annual Review of Medicine·Maria Domenica Cappellini, Paolo Pattoneri
May 25, 2010·Orphanet Journal of Rare Diseases·Renzo Galanello, Raffaella Origa
Nov 1, 2012·Journal of Blood Medicine·Vasilios BerdoukasThomas Coates
Jul 6, 2014·Clinical Pharmacokinetics·Chiaki Tanaka
Sep 14, 2011·Hemoglobin·Khaled M Musallam, Ali T Taher
Jul 16, 2015·Hemoglobin·Efthymia VlachakiPanagiota Boura
Aug 2, 2011·Expert Review of Hematology·Khaled M Musallam
Apr 5, 2016·Pharmacogenomics·Jessica CusatoAntonio D'Avolio
May 26, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Husain AttarwalaMansoor Amiji
May 13, 2017·The International Journal of Biochemistry & Cell Biology·Md Khadem AliJay C Horvat
Feb 20, 2014·Metallomics : Integrated Biometal Science·Douglas B Kell, Etheresia Pretorius
Aug 22, 2013·The Cochrane Database of Systematic Reviews·Sheila A FisherDavid J Roberts
Jun 4, 2014·The Cochrane Database of Systematic Reviews·Joerg J MeerpohlDirk Bassler
Nov 15, 2019·Nature Communications·Homan KangJonghan Kim
Jul 5, 2021·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Estelle Jean-MignardIsabelle Thuret

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