Long-term exposure to fluoxetine reduces growth and reproductive potential in the dominant rocky intertidal mussel, Mytilus californianus

The Science of the Total Environment
Joseph R Peters, Elise F Granek

Abstract

Environmental stressors shape community composition and ecosystem functioning. Contaminants such as pharmaceuticals are of increasing concern as an environmental stressor due to their persistence in surface waters worldwide. Limited attention has been paid to the effects of pharmaceuticals on marine life, despite widespread detection of these contaminants in the marine environment. Of the existing studies, the majority assess the negative effects of pharmaceuticals over an exposure period of 30 days or less and focus on cellular and subcellular biomarkers. Longer studies are required to determine if chronic contaminant exposure poses risks to marine life at environmentally relevant concentrations; and examination of whole organism effects are necessary to identify potential community-level consequences in estuarine and marine ecosystems. We conducted a long-term exposure study (107 days) with the anti-depressant pharmaceutical, fluoxetine (the active constituent in Prozac®) to determine whether minimal concentrations affected whole organism metrics in the California mussel, Mytilus californianus. We measured algal clearance rates, mussel growth, and the gonadosomatic index, a measure of reproductive health. We found that fluoxe...Continue Reading

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Citations

Sep 13, 2016·Environmental Science and Pollution Research International·Emma Prichard, Elise F Granek
Sep 14, 2018·The Science of the Total Environment·Jack B FursdonBob B M Wong
Sep 7, 2020·The Science of the Total Environment·Jianwei ZhaoYingjie Sun
Aug 15, 2017·Marine Environmental Research·Jonny BeyerMerete Schøyen
Jun 20, 2020·Environmental Science & Technology·Sarah C WilesBob B M Wong
Dec 3, 2021·The Science of the Total Environment·Alexandra G TissotKaegan Scully-Engelmeyer

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