Long-term exposure to residential ambient fine and coarse particulate matter and incident hypertension in post-menopausal women

Environment International
Trenton HondaGregory A Wellenius

Abstract

Long-term exposure to ambient particulate matter (PM) has been previously linked with higher risk of cardiovascular events. This association may be mediated, at least partly, by increasing the risk of incident hypertension, a key determinant of cardiovascular risk. However, whether long-term exposure to PM is associated with incident hypertension remains unclear. Using national geostatistical models incorporating geographic covariates and spatial smoothing, we estimated annual average concentrations of residential fine (PM2.5), respirable (PM10), and course (PM10-2.5) fractions of particulate matter among 44,255 post-menopausal women free of hypertension enrolled in the Women's Health Initiative (WHI) clinical trials. We used time-varying Cox proportional hazards models to evaluate the association between long-term average residential pollutant concentrations and incident hypertension, adjusting for potential confounding by sociodemographic factors, medical history, neighborhood socioeconomic measures, WHI study clinical site, clinical trial, and randomization arm. During 298,383 person-years of follow-up, 14,511 participants developed incident hypertension. The adjusted hazard ratios per interquartile range (IQR) increase in P...Continue Reading

Citations

Jul 27, 2018·The American Journal of Nursing·Jessica Castner, Barbara J Polivka
Mar 16, 2018·Stroke; a Journal of Cerebral Circulation·Erin R KulickMitchell S Elkind
Sep 9, 2019·Environmental Science and Pollution Research International·Ramin NabizadehMostafa Hadei
Feb 6, 2020·Biometrical Journal. Biometrische Zeitschrift·Yishu WangMichal Abrahamowicz
Dec 11, 2020·International Journal of Environmental Research and Public Health·Myung-Jae HwangHae-Kwan Cheong
Nov 7, 2020·Environmental Health : a Global Access Science Source·Emilie DavisXiangmei May Wu
Oct 7, 2021·Scientific Reports·Viyey Doulatram-GamgaramGemma Rojo-Martínez

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