Long-term exposure to very low doses of bisphenol S affects female reproduction

Reproduction : the Official Journal of the Society for the Study of Fertility
Jan NevoralMilena Králíčková

Abstract

Bisphenols belong to the endocrine disruptors, affecting reproduction even in extremely low doses. Bisphenol S (BPS) has become widely used as a substitute for the earlier-used bisphenol A; however, its harmlessness is questionable. The aim of this study was to evaluate the effect of BPS on folliculogenesis and oocyte quality after in vivo exposure to low doses of BPS. Four-week-old ICR females (n = 16 in each experimental group) were exposed to vehicle control (VC), BPS1 (0.001 ng BPS.g/bw/day), BPS2 (0.1 ng.g/bw/day), BPS3 (10 ng.g/bw/day) and BPS4 (100 ng.g/bw/day) for 4 weeks. Ovaries were subjected to stereology and nano liquid chromatography-mass spectrometry (LC/MS). Simultaneously, metaphase II oocytes were obtained after pregnant mare serum gonadotrophin and human chorionic gonadotrophin administration, followed by immunostaining. In particular, mating and two-cell embryo flushing were performed. We observed that BPS decreases the amount of ovarian follicles and BPS2 (0.1 ng.g/bw/day) affects the volume of antral follicles. Accordingly, ovarian proteome is affected after BPS2 treatment. While BPS2 dosing results mainly in cytoskeletal damage in matured oocytes, the effects of BPS3 and BPS4 seem to be due instead to epi...Continue Reading

References

Sep 1, 1990·Journal of Microscopy·T MattfeldtP Möller
Oct 1, 1993·Environmental Health Perspectives·T ColbornA M Soto
Sep 22, 2001·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Y HashimotoM Nakamura
Jan 5, 2002·Molecular Reproduction and Development·Marziel KamjooSusan J Kimber
Feb 19, 2002·Environmental Toxicology·Min-Yu ChenMasanori Fujita
Dec 7, 2002·Behavior Genetics·Alexander A BachmanovMichael G Tordoff
Dec 19, 2002·Occupational Medicine·D Coggon
Apr 5, 2003·Current Biology : CB·Patricia A HuntTerry J Hassold
Oct 29, 2004·Reproduction : the Official Journal of the Society for the Study of Fertility·Dagmar ZudovaFrancesco Marchetti
Jan 7, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Shigeyuki KitamuraShigeru Ohta
Nov 1, 2005·Theriogenology·Marc-André SirardClaude Robert
Jun 6, 2006·Water Science and Technology : a Journal of the International Association on Water Pollution Research·M IkeM Fujita
Aug 26, 2006·Developmental Biology·Sarah K Bristol-GouldTeresa K Woodruff
Aug 3, 2007·Proceedings of the National Academy of Sciences of the United States of America·Dana C DolinoyRandy L Jirtle
Dec 22, 2007·Mutation Research·Ursula Eichenlaub-RitterJim Parry
May 15, 2009·International Journal of Environmental Research and Public Health·Erica DanzlMasanori Fujita
May 16, 2009·Biomedical Chromatography : BMC·Luigi CobellisLucia Grumetto
Dec 17, 2009·International Journal of Andrology·E Mok-LinR Hauser
Oct 20, 2010·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jackye PeretzJodi A Flaws
Jan 1, 2005·Environmental Toxicology and Pharmacology·Ryoko Kuruto-NiwaYoshiyasu Terao
Mar 16, 2012·Endocrine Reviews·Laura N VandenbergJohn Peterson Myers
Apr 18, 2012·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Elise GrignardSusanne Bremer
May 18, 2012·Environmental Science & Technology·Chunyang LiaoKurunthachalam Kannan
May 25, 2012·Environmental Science & Technology·Chunyang LiaoKurunthachalam Kannan
Aug 29, 2012·Proceedings of the National Academy of Sciences of the United States of America·Vanessa DelfossePatrick Balaguer
Mar 5, 2013·Environmental Health Perspectives·Julia R Barrett
Jun 29, 2013·Environmental Science & Technology·Kyunghee JiKyungho Choi
Feb 25, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Anna Kjerstine RosenmaiAnne Marie Vinggaard
Apr 8, 2014·Chemosphere·Gregory J Howard
Apr 18, 2014·Nature·Josie Glausiusz
Jun 5, 2014·Environmental Health Perspectives·Jackye PeretzJodi A Flaws
Mar 17, 2015·Toxicology and Applied Pharmacology·Ayelet Ziv-GalJodi A Flaws
Mar 17, 2015·Scientific Reports·Md Saidur RahmanMyung-Geol Pang
Mar 17, 2015·Environmental Health Perspectives·Johanna R Rochester, Ashley L Bolden
Mar 18, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Oscar E RiveraEnrique H Luque
Apr 9, 2015·Journal of Cancer Prevention·Oneyeol YangYoung Rok Seo
May 30, 2015·Reproduction : the Official Journal of the Society for the Study of Fertility·Chiara MannelliDariusz Jan Skarzynski
Sep 27, 2015·Journal of Toxicology and Environmental Health. Part a·Bruno Alves RochaFernando Barbosa

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Citations

May 28, 2019·Toxicological Sciences : an Official Journal of the Society of Toxicology·Mingxin ShiKanako Hayashi
Feb 16, 2020·International Journal of Molecular Sciences·Alice DesmarchaisSebastien Elis
Mar 12, 2020·International Journal of Molecular Sciences·Sarah AmarSebastien Elis
May 30, 2020·Reproductive Biology and Endocrinology : RB&E·Hedvika ŘimnáčováJan Nevoral
Sep 1, 2020·Environmental Pollution·Ming-Yu ZhangShun-Feng Cheng
Mar 3, 2020·Environment International·Vicente MustielesCarmen Messerlian
May 18, 2021·Current Opinion in Endocrine and Metabolic Research·Alison M Neff, Jodi A Flaws
Jul 17, 2021·Biology of Reproduction·Marilin ProfitaPaola Valbonesi

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