Long-term facilitation of ipsilateral but not contralateral phrenic output after cervical spinal cord hemisection

Experimental Neurology
N J Doperalski, D D Fuller

Abstract

After chronic C2 spinal hemisection (C2HS), exposure to intermittent hypoxia (IH) evokes a persistent increase in phrenic output recorded ipsilateral to the injury (i.e., phrenic long-term facilitation, LTF; Golder and Mitchell, J. Neurosci. 25:2925-32, 2005). However, unilateral spinal cord injury induces compensatory increases in contralateral motoneuron activity that may reduce their capacity for further plasticity (i.e., a "ceiling effect"). We hypothesized that after chronic C2HS, LTF would be reduced in contralateral (vs. ipsilateral) phrenic output. Bilateral phrenic activity was recorded in three groups of anesthetized, paralyzed, vagotomized, and ventilated rats: uninjured, and 4 or 8 weeks following histologically verified C2HS. Baseline (BL) phrenic activity was established during normoxia and rats were then exposed to IH (5 x 3 min isocapnic hypoxia, 13-14% O2) followed by isocapnic normoxia; LTF was assessed 60-min post-IH. Uninjured animals showed an increase in inspiratory burst amplitude that was similar in the left (44 +/- 11%BL) and right phrenic nerves (39 +/- 13%BL). However, similar burst amplitude LTF did not occur in phrenic output recorded contralateral to C2HS at 4 (-10 +/- 7% BL) or 8 weeks post-C2HS (...Continue Reading

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Citations

Aug 7, 2009·Journal of Neurophysiology·Kun-Ze LeeDavid D Fuller
Jun 19, 2012·Respiratory Physiology & Neurobiology·B J DoughertyD D Fuller
Nov 2, 2011·Respiratory Physiology & Neurobiology·James A Windelborn, Gordon S Mitchell
Aug 5, 2009·Respiratory Physiology & Neurobiology·Stéphane VinitGordon S Mitchell
Aug 18, 2009·Respiratory Physiology & Neurobiology·Stéphane Vinit, Anne Kastner
Jan 20, 2009·Respiratory Physiology & Neurobiology·D D FullerP J Reier
Jul 1, 2008·Respiratory Physiology & Neurobiology·N J DoperalskiD D Fuller
May 3, 2008·Respiratory Physiology & Neurobiology·Tracy L Baker-Herman, Gordon S Mitchell
Jul 3, 2007·Experimental Neurology·M Beth ZimmerHarry G Goshgarian
Oct 19, 2006·Experimental Neurology·M Beth Zimmer, Harry G Goshgarian
Jun 10, 2015·Experimental Neurology·Michael George Zaki Ghali, Vitaliy Marchenko
Nov 7, 2013·Experimental Neurology·Kun-Ze LeeDavid D Fuller
Sep 10, 2013·Experimental Neurology·M S SandhuD D Fuller
Apr 28, 2017·Journal of Neurotrauma·Kun-Ze Lee, Shih-Hui Hsu
Jun 27, 2018·Journal of Neurotrauma·Kun-Ze Lee, Ke-Jun Xu
Jun 12, 2010·Annals of the New York Academy of Sciences·Erica A Dale-NagleGordon S Mitchell
Nov 29, 2013·Journal of Applied Physiology·Kun-Ze LeeI-Lun Tsai
Aug 15, 2015·Journal of Applied Physiology·Abdulghani SankariM Safwan Badr
Aug 2, 2017·Neural Regeneration Research·Michael George Zaki Ghali
Oct 9, 2021·Frontiers in Cellular Neuroscience·Margo RandelmanMichael A Lane

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