Abstract
We investigated whether fatty liver preceded insulin resistance or vice versa using a long-term orotic acid (OA)-induced nonalcoholic fatty liver disease (NAFLD) model without the confounding effects of obesity and hyperlipidemia and explored the role of the liver in insulin resistance. Male Wistar rats were fed with or without OA supplementation for 30, 60, and 90 days. The NAFLD group showed increased liver lipid at 30, 60, and 90 days; glucose intolerance was noted at 60 and 90 days. Furthermore, partial liver proteins and gene expressions related to upstream signaling of insulin were decreased. However, the liver glycogen content was elevated, and gluconeogenesis genes expressions were obviously decreased at 90 days. The occurrence of fatty liver preceded insulin resistance in OA-induced NAFLD without the interference of obesity and hyperlipidemia, and hepatic insulin resistance may not play a conclusive role in insulin resistance in this model.
References
May 8, 1998·Bioscience, Biotechnology, and Biochemistry·J Y ChaT Yanagita
Jun 24, 2000·Diabetes·P A LochheadC Sutherland
Jul 21, 2000·The Journal of Clinical Investigation·G I Shulman
Mar 16, 2001·Endocrine Practice : Official Journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists·G Boden
Oct 5, 2001·Nature Reviews. Molecular Cell Biology·P Cohen, S Frame
Apr 19, 2002·The New England Journal of Medicine·Paul Angulo
Sep 10, 2003·American Journal of Physiology. Endocrinology and Metabolism·Andreas Barthel, Dieter Schmoll
Oct 1, 1955·Proceedings of the Society for Experimental Biology and Medicine·S B STANDERFER, P HANDLER
May 29, 2004·The Journal of Biological Chemistry·Varman T SamuelGerald I Shulman
May 4, 2005·The Journal of Allergy and Clinical Immunology·Giamila Fantuzzi
Nov 9, 2005·Circulation·Peter W F WilsonJames B Meigs
Dec 15, 2006·Nature·Jean-Pierre Després, Isabelle Lemieux
Aug 11, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Anna Kotronen, Hannele Yki-Järvinen
Dec 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisa FabbriniSamuel Klein
Aug 7, 2010·The Journal of Biological Chemistry·Ji-Min LeeHueng-Sik Choi
Dec 21, 2010·Nutrition·Yu-Ming WangChang-Hu Xue
Jun 28, 2011·Science·Jonathan C CohenHelen H Hobbs
Sep 21, 2011·Proceedings of the National Academy of Sciences of the United States of America·Naoki KumashiroGerald I Shulman
Oct 8, 2011·The Journal of Veterinary Medical Science·Naohito NishiiYoshiaki Hikasa
Mar 20, 2012·Gastroenterology·Faidon MagkosSamuel Klein
Jan 18, 2014·American Journal of Physiology. Gastrointestinal and Liver Physiology·Akihiro AsaiXiao-Di Tan
Mar 25, 2015·Journal of Diabetes Investigation·Ken-Ichiro KatoToshinari Takamura
Citations
Aug 26, 2016·Lipids in Health and Disease·Miao-Miao ZhouChang-Hu Xue
Jun 15, 2019·Food & Function·Xiu-Qing HanYu-Ming Wang
Oct 1, 2019·Public Health Nutrition·Mian-Li XiaoYu-Ming Chen
Oct 28, 2019·Canadian Journal of Physiology and Pharmacology·Dionysius SubaliHee Eun Kang
Aug 16, 2018·Royal Society Open Science·Ying GuoYuming Wang
Jul 5, 2019·The Science of the Total Environment·Marie UsalStéphane Reynaud
Apr 30, 2021·Fundamental & Clinical Pharmacology·Hee Jin JeongHee Eun Kang
Jan 19, 2018·Journal of Agricultural and Food Chemistry·Mengru ChangYuming Wang