Long-term feeding of field bean protein containing protease inhibitors suppresses virus-induced mammary tumors in mice

Cancer Letters
A Fernandes, A Banerji

Abstract

Protease inhibitors (PIs) of synthetic, bacterial or soybean origin have been shown to suppress carcinogen or radiation-induced rat mammary carcinogenesis. We report, for the first time, the effect of year-long feeding of Field bean meal, a rich source of PIs with a 24% protein content, at different protein levels in the diet, on mouse mammary tumor virus (MMTV)-induced mammary tumorigenesis in C3H/Jax mice. Weanling female mice were randomized and divided into groups and fed chow or chow with 2%, 4%, 8% FB protein (FBP) or autoclaved 2% FBP (AFBP) until 49 weeks and the incidence of mammary tumors was recorded until 58 weeks when they were sacrificed. Mice fed 2% FBP showed significant (P < 0.001) reduction (68%) in tumor incidence and delay (P < 0.02) in tumor appearance compared to controls. This suppressive effect on mammary tumorigenesis increased with increased FBP intake with values of tumor suppression being 75% and 81% in mice groups fed 4% and 8% FBP, respectively. Incidentally, the tumors appeared earlier (P < 0.05) in the 8% FBP-treated mice compared to other groups. Moreover, this suppressive effect on mammary tumorigenesis was related to the PI activity of the FB meal, since mice fed 2% AFBP showed no reduction in...Continue Reading

References

Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·P AshornB Moss
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