Long-term flaxseed oil supplementation diet protects BALB/c mice against Streptococcus pneumoniae infection.

Medical Microbiology and Immunology
A SainiSanjay Chhibber

Abstract

Intense host immune response to infection contributes significantly to the pathology of pneumococcal pneumonia. Therefore, the regulation of host immune response is critical for the successful outcome of pneumonia in such patients. The aim of the present study was to investigate the effect of n-3 PUFA, i.e. flaxseed oil supplementation for short (4 weeks) as well as long (9 weeks) term, on the course of S. pneumoniae D39 serotype 2 infection in mice. The efficacy of flaxseed oil supplementation was investigated in terms of survival of animals and production of various inflammatory molecules (malondialdehyde, myeloperoxidase, nitric oxide) in the lung homogenate of animals. This was correlated with bacteriological and histopathological parameters. The immunomodulation was studied in terms of cytokines in the lungs following infection with Streptococcus pneumoniae. Results suggest that long-term flaxseed supplementation protected the mice against bacterial colonization of lungs with Streptococcus pneumoniae with reduced histopathological involvement of lung tissue. Moderate pneumonia was observed in supplemented, infected mice compared to severe pneumonia seen in control mice. This was accompanied by decreased inflammatory marker...Continue Reading

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Citations

Nov 18, 2010·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·A SainiS Chhibber
Apr 2, 2015·Journal of Food Science and Technology·Priyanka KajlaDev Raj Sood
Oct 30, 2016·The Journal of Infection·Marie-Odile HussonFrédéric Gottrand
Nov 6, 2014·Jundishapur Journal of Microbiology·Mohammad FallahRasoul Yousefi Mashouf

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