Long-term fluctuation of relative afferent pupillary defect in subjects with normal visual function

American Journal of Ophthalmology
A KawasakiR H Kardon

Abstract

To determine whether the relative afferent pupillary defect (RAPD) remains constant over time in normal subjects. Seventeen normal subjects were tested with infrared pupillography and automated perimetry in four sessions over 3 years. The changes in RAPD and visual field asymmetry between testing sessions were compared. The range of RAPD was 0.0 to 0.3 log unit, and the difference in the mean deviation between the eyes on automated static perimetry was 0 to 3 dB. Eight subjects repeatedly had an RAPD in the same eye. There was no correlation between the RAPD and the visual field asymmetry at the same visit. Changes in the magnitude of the RAPD between any two sessions were typically small (median, 0.08 log unit; 25th percentile, 0.04 log unit; 75th percentile, 0.15 log unit). Some normal subjects may show a persistent but small RAPD in the absence of detectable pathologic disease. Therefore, an isolated RAPD in the range of 0.3 log unit that is not associated with any other significant historical or clinical finding should probably be considered benign.

References

Jul 1, 1984·Journal of Neurology, Neurosurgery, and Psychiatry·C J Ellis

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Citations

Apr 3, 2002·Ophthalmology·Oliver Bergamin, Randy H Kardon
Mar 23, 2006·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Flemming StaubachWolf A Lagrèze
Oct 3, 2012·Journal of the Neurological Sciences·Paul BlazekElliot M Frohman
Jan 1, 2008·Journal of Cataract and Refractive Surgery·Hema ShankarKonrad Pesudovs
Nov 7, 2015·Zeitschrift für medizinische Physik·Alan Cayless, Thomas Bende
Mar 5, 2003·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Helmut Wilhelm, Barbara Wilhelm
May 15, 2001·Optometry and Vision Science : Official Publication of the American Academy of Optometry·E Besada, J P Fisher
Jul 9, 2014·Nature Reviews. Neurology·Axel PetzoldGordon T Plant
Oct 5, 2018·European Journal of Ophthalmology·Esat YetkinHakan Halit Yasar
Nov 10, 2004·Eye·F D Bremner
Dec 20, 2007·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Helmut WilhelmBarbara Wilhelm
Jun 8, 2017·Therapeutic Advances in Urology·Hande Hüsniye TelekAli Ayyildiz
Mar 24, 1999·American Journal of Ophthalmology·S P DonahueR H Kardon

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