Long-term follow up after endoscopic valve therapy in patients with severe emphysema

Therapeutic Advances in Respiratory Disease
Daniela GompelmannFelix J F Herth

Abstract

Endoscopic valve therapy is a treatment modality in patients with advanced emphysema and absent interlobar collateral ventilation (CV). So far, long-term outcome following valve implantation has been insufficiently evaluated. The aim of this study was to investigate the real-world efficacy of this interventional therapy over 3 years. From 2006 to 2013, 256 patients with severe emphysema in whom absent CV was confirmed underwent valve therapy. The 3-year effectiveness was evaluated by pulmonary function testing (VC, FEV1, RV, TLC), 6-minute-walk test (6-MWT) and dyspnea questionnaire (mMRC). Long-term outcome was also assessed according to the radiological outcome following valve placement. Of 256 patients treated with valves, 220, 200, 187, 100 and 66 patients completed the 3-month, 6-month, 1-year, 2-year and 3-year follow-up (FU) visit, respectively. All lung function parameters, 6-MWT and mMRC were significantly improved at 3- and 6-month FU. At 1-year FU, patients still experienced a significant improvement of all outcome parameters expect VC (L) and TLC (%). At 2 years, RV (L and %) and TLC (L and %) remained significantly improved compared to baseline. Three years after valve therapy, sustained significant improvement in ...Continue Reading

References

Apr 26, 2003·American Journal of Respiratory and Critical Care Medicine·Dina BrooksWilliam J Gibbons
Aug 2, 2005·The European Respiratory Journal·M R MillerUNKNOWN ATS/ERS Task Force
Sep 2, 2005·The European Respiratory Journal·J WangerG Viegi
Aug 10, 2010·The European Respiratory Journal·M A PuhanUNKNOWN National Emphysema Treatment Trial (NETT) Research Group
Sep 24, 2010·The New England Journal of Medicine·Frank C SciurbaUNKNOWN VENT Study Research Group
Oct 16, 2010·The European Respiratory Journal·N S HopkinsonM I Polkey
Oct 19, 2011·The European Respiratory Journal·Federico VenutaGiorgio F Coloni
Mar 24, 2012·The European Respiratory Journal·Jorine E HartmanDirk-Jan Slebos
May 5, 2012·The European Respiratory Journal·Felix J F HerthDirk-Jan Slebos
Mar 13, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Daniela GompelmannJonathan Goldin
Nov 25, 2014·Respirology : Official Journal of the Asian Pacific Society of Respirology·Jorine E HartmanDirk-Jan Slebos
Jan 31, 2015·American Journal of Respiratory and Critical Care Medicine·Maren SchuhmannFelix J F Herth
Dec 10, 2015·The New England Journal of Medicine·Karin KloosterDirk-Jan Slebos
Nov 1, 2016·American Journal of Respiratory and Critical Care Medicine·Arschang ValipourUNKNOWN IMPACT Study Team
Dec 16, 2016·Respiration; International Review of Thoracic Diseases·Karin KloosterDirk-Jan Slebos
Dec 20, 2016·Respiration; International Review of Thoracic Diseases·Dirk-Jan SlebosArschang Valipour
Dec 21, 2016·International Journal of Chronic Obstructive Pulmonary Disease·D GompelmannR Eberhardt
Sep 9, 2017·American Journal of Respiratory and Critical Care Medicine·Samuel V KempUNKNOWN TRANSFORM Study Team *
Feb 15, 2018·International Journal of Chronic Obstructive Pulmonary Disease·D GompelmannF J Herth
May 23, 2018·American Journal of Respiratory and Critical Care Medicine·Gerard J CrinerUNKNOWN LIBERATE Study Group
Sep 19, 2018·Respiration; International Review of Thoracic Diseases·Daniela GompelmannRalf Eberhardt

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Citations

May 5, 2020·Respirology : Official Journal of the Asian Pacific Society of Respirology·Pallav L Shah, Dirk-Jan Slebos
Aug 28, 2020·Expert Review of Respiratory Medicine·T David KosterDirk-Jan Slebos
May 21, 2020·Seminars in Respiratory and Critical Care Medicine·Justin L Garner, Pallav L Shah
Mar 3, 2021·European Respiratory Review : an Official Journal of the European Respiratory Society·Jeanne Marie PerotinGaëtan Deslee
Jun 5, 2021·ERJ Open Research·Christophe DoomsWim Janssens
Jul 9, 2021·International Journal of Chronic Obstructive Pulmonary Disease·Thomas EgenodMatthieu Dusselier
Aug 13, 2021·The Medical Journal of Australia·Alan M CarewAlvin Ing
Nov 2, 2021·Current Opinion in Pulmonary Medicine·Justin L Garner, Pallav L Shah

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