Long-term follow-up after near-infrared fluorescence-guided resection of colorectal liver metastases: A retrospective multicenter analysis

European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology
Henricus J M HandgraafA L Vahrmeijer

Abstract

Several studies demonstrated that intraoperative near-infrared fluorescence (NIRF) imaging using indocyanine green (ICG) identifies (sub)capsular colorectal liver metastases (CRLM) missed by other techniques. It is unclear if this results in any survival benefit. This study evaluates long-term follow-up after NIRF-guided resection of CRLM using ICG. First, patients undergoing resection of CRLM with or without NIRF imaging were analyzed retrospectively. Perioperative details, liver-specific recurrence-free interval and overall survival were compared. Second, the prognosis of patients in whom additional metastases were identified solely by NIRF was studied. Eighty-six patients underwent resection with NIRF imaging and 87 without. In significantly more patients of the NIRF imaging cohort additional metastases were identified during surgery (25% vs. 13%, p = 0.04). Tumors identified solely by NIRF imaging were significantly smaller compared to additional metastases identified also by inspection, palpation or intraoperative ultrasound (3.2 ± 1.8 mm vs. 7.4 ± 2.6 mm, p < 0.001). Liver-specific recurrence-free survival at 4 years was 47% with NIRF imaging and 39% without (hazard ratio at multivariate analysis 0.73, 95% CI 0.42-1.28, p...Continue Reading

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Jun 26, 2018·Journal of Surgical Oncology·Labrinus van ManenJan Sven David Mieog
Jan 6, 2018·Surgical Innovation·Eva LietoAnnamaria Auricchio
May 20, 2020·Der Chirurg; Zeitschrift für alle Gebiete der operativen Medizen·R SucherD Seehofer
Aug 12, 2018·Journal of Surgical Oncology·Yuichi NakasekoAkio Saiura
Feb 7, 2018·Clinical Orthopaedics and Related Research·Mitchell S FourmanKurt R Weiss
Nov 8, 2020·European Journal of Surgical Oncology : the Journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology·Ruben P J MeijerAlexander L Vahrmeijer
Jan 29, 2021·Journal of Clinical Medicine·Anne-Sophie MehdornJan-Hendrik Egberts
Aug 15, 2019·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Marco Vito MarinoManuel G Fleitas
May 10, 2021·Surgical Endoscopy·Trevor M Yeung
May 6, 2021·International Journal of Molecular Sciences·Vincent Q SierLukas J A C Hawinkels
Dec 23, 2020·Annals of Surgery·Xiaoying WangNorihiro Kokudo
May 19, 2021·International Journal of Surgery Case Reports·Till M HempfingThomas Steffen

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