Long-term follow-up and risk of cancer death after radiation for post-prostatectomy rising prostate-specific antigen

International Journal of Radiation Oncology, Biology, Physics
Gregory P SwansonMichael Hermans

Abstract

The results of salvage radiation therapy for rising prostate-specific antigen (PSA) levels after radical prostatectomy appear favorable, but the ultimate outcome is uncertain, given the relatively short follow-up in most studies. We report on a group of patients at a median follow-up of 13.9 years after salvage radiation therapy. From 1990 to 1995, 92 patients were referred postoperatively for radiation for a rising PSA level. PSA level at the time of referral ranged from 0.1 to 30.5 ng/ml (median, 1.5 ng/ml). The median time from surgery to radiation was 2.1 years (range,, 0.3-7.4 years). Radiation was directed to the prostatic fossa only with a median dose of 6,500 cGy (range, 6,000-7,000 cGy). Eighty-five patients experienced a PSA drop after radiation, as predicted by Gleason score and PSA level at the start of radiation. Five- and 10-year biochemical failure free survival (BFFS) was 35% and 26%, respectively, and overall survival was 86% and 67%, respectively. Median survival was 12.0 years, and median BFF was 2.3 years. The presurgery PSA level was not predictive, but the PSA level at the start of radiation predicted a response. Patients with Gleason 8 to 9 cancers had a significantly higher progression rate than those wi...Continue Reading

References

Nov 7, 1998·International Journal of Radiation Oncology, Biology, Physics·R K ValicentiB W Corn
Aug 16, 2005·Lancet·Michel BollaUNKNOWN European Organization for Research and Treatment of Cancer
Feb 6, 2007·International Journal of Radiation Oncology, Biology, Physics·Dirk NeuhofJuergen Debus
Dec 1, 2007·Urologic Oncology·Gregory P Swanson, Ian M Thompson
Jun 19, 2008·JAMA : the Journal of the American Medical Association·Bruce J TrockPatrick C Walsh

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Citations

Apr 12, 2013·European Journal of Nuclear Medicine and Molecular Imaging·S M SchwarzenböckB J Krause
May 8, 2013·Future Oncology·Detlef BartkowiakThomas Wiegel
Sep 12, 2014·International Journal of Urology : Official Journal of the Japanese Urological Association·Ji Hyun ChangSeong Il Seo
Jun 1, 2016·Frontiers in Oncology·Fernanda G Herrera, Dominik R Berthold

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