Long-term follow-up and safety of vandetanib for advanced medullary thyroid cancer.

Endocrine
Helton Estrela RamosMartin Schlumberger

Abstract

Vandetanib is indicated for adults with advanced medullary thyroid cancer (MTC). To describe the efficacy and toxicity profile of vandetanib treatment with a maximal follow-up of 11 years at Institut Gustave Roussy/France. A review of the clinical files of the 76 MTC patients treated with vandetanib. Efficacy was estimated by markers and imaging. A total of 76 patients received vandetanib. Nine were excluded from efficacy analysis because lack of morphological data. The overall (N = 76) median treatment duration was 17.6 (range: 0.7-130.6) months and the median progression-free survival (PFS) was 22.7 (95% CI, 13.9-37.3) months. In total, 21/76 (27.6%) patients were classified as long-term users because have received vandetanib for more than 48 months, with a median treatment duration of 68.1 (range: 49.1-130.6) months. For long-term vandetanib users, the objective response rate was 85.7%, the median time to best response was 27.8 (11.6.1-110) months and the median duration of response was 70.4 (38.3-127.5) (95% CI 49.5-102.8) months with a median PFS of 73.2 (95% CI, 53.1-105.6) months. Duration of response had a significant negative correlation with patient age at diagnosis (p = 0.03) and was significantly higher in patients ...Continue Reading

References

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Citations

Apr 4, 2021·International Journal of Molecular Sciences·Loredana LorussoRossella Elisei
Oct 9, 2021·Journal of Cutaneous Pathology·Riyad N H SeervaiJonathan L Curry

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