PMID: 2124245Dec 1, 1990Paper

Long-term follow-up of 120 patients with AIDS-related Kaposi's sarcoma treated with interferon alpha-2a

The Journal of Investigative Dermatology
W RozenbaumC Rouzioux

Abstract

One hundred and twenty patients suffering from an AIDS-related Kaposi's sarcoma treated by 18 million units of recombinant alpha-2A-interferon daily were followed prospectively for a period of between one and six years. An overall complete response was observed in 35% of these patients; the figure was significantly higher in those who did not have a visceral localization or opportunistic infections. Total lymphocyte count, CD4 lymphocyte count, and CD4/CD8 ratio were significantly higher, and beta-2-microglobuline significantly lower, in the responders than in the non-responders. A multivariate analysis showed that localization of KS and CD4 count had independent predictive value, with an odds ratio of 35 for patients who had more than 300 CD4 cells at the onset of treatment versus those with less than 150. Patients whose initially negative p24 antigenemia remained negative during treatment had the highest frequency of complete response. Among patients with initially positive p24 antigenemia, those whose percentage decrease in antigenemia levels was greatest had a higher frequency of complete response. The cumulative probability of survival in responders was 62% at four years. These results demonstrate an anti-tumoral and anti-...Continue Reading

Citations

Nov 1, 1994·International Journal of Dermatology·T H Finesmith, J P Shrum
Sep 14, 2001·Current Opinion in Oncology·S E Krown
May 19, 2017·The Journal of Infectious Diseases·James L Riley, Luis J Montaner
Jun 30, 2019·The Journal of Immunology : Official Journal of the American Association of Immunologists·Emmanouil PapasavvasLuis J Montaner
Jan 1, 1997·Clinical Oncology : a Journal of the Royal College of Radiologists·C P CottrillR H Phillips

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