Long-term follow-up of 241 patients with monoclonal gammopathy of undetermined significance: the original Mayo Clinic series 25 years later

Mayo Clinic Proceedings
Robert A KyleL Joseph Melton

Abstract

To determine the long-term outcome of patients with monoclonal gammopathy of undetermined significance (MGUS). We reviewed the medical records of 241 patients with MGUS who were examined at the Mayo Clinic in Rochester, Minn, between January 1, 1956, and December 31, 1970. Follow-up was 3579 person-years (median, 13.7 years; range, 0-39 years). Only 14 patients (6%) were alive and had no substantial increase of M protein at last follow-up; 138 patients (57%) died without evidence of multiple myeloma or a related disorder; a malignant lymphoplasma cell proliferative disorder developed in 64 patients (27%). The interval from diagnosis of MGUS to diagnosis of multiple myeloma or related disorder ranged from 1 to 32 years (median, 10.4 years). The median survival rate of study patients with MGUS was only slightly shorter than that of a comparable US population. Risk of progression of MGUS to lymphoplasma cell malignancy is indefinite and persists even after more than 30 years of follow-up, with no reliable predictors of malignant evolution.

References

Jun 1, 1978·Clinical Immunology and Immunopathology·F D Lindström, U Dahlström
Jan 1, 1978·Acta Medica Scandinavica·S PeltonenO Wager
May 1, 1978·The American Journal of Medicine·R A Kyle
Nov 1, 1987·Mayo Clinic Proceedings·P R GreippR A Kyle
Mar 1, 1986·Scandinavian Journal of Haematology·J Møller-Petersen, E B Schmidt
Feb 1, 1966·Acta Medica Scandinavica·U AxelssonJ Hällén
Nov 1, 1968·Acta Medica Scandinavica·F Dammacco, J Waldenström
Aug 1, 1973·The American Journal of Medicine·R A KyleE D Bayrd
Jan 1, 1982·Journal of Clinical Pathology·J P SaleunJ F Morin
Jun 12, 1980·The New England Journal of Medicine·R A Kyle, P R Greipp
Jan 1, 1993·Mayo Clinic Proceedings·R A Kyle
Feb 22, 2002·The New England Journal of Medicine·Robert A KyleL Joseph Melton
Mar 16, 2002·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Clara CesanaEnrica Morra

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Citations

Dec 10, 2009·Haematologica·Robert A Kyle, Shaji Kumar
Oct 28, 2014·Cancer Research and Treatment : Official Journal of Korean Cancer Association·Yun-Gyoo LeeJong-Seok Lee
Jan 17, 2019·BMC Bioinformatics·Apostolos DimitromanolakisLaurent Briollais
Jan 5, 2020·Journal of Cardiovascular Translational Research·Zhao XuJunbo Ge
Aug 20, 2005·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Shaji KumarThomas E Witzig
Dec 29, 2006·The New England Journal of Medicine·Joan Bladé
Apr 4, 2007·International Journal of Cancer. Journal International Du Cancer·Dominik D AlexanderDimitrios Trichopoulos
Dec 24, 2011·International Journal of Hematology·Mohamed M El-DifrawyAhmed M Farag
Nov 11, 2016·BMC Medical Research Methodology·Krystal BerginAndrew Spencer
Mar 31, 2006·The New England Journal of Medicine·Robert A KyleL Joseph Melton
Nov 9, 2007·International Journal of Cancer. Journal International Du Cancer·Mary L McMaster, Gyorgy Csako
Jul 29, 2009·Leukemia & Lymphoma·Sasa A ZivkovićSuzanne Lentzsch
Jun 19, 2013·Annals of Medicine·Jo CaersUNKNOWN Multiple Myeloma Study Group of the Belgian Hematological Society
Sep 20, 2018·Current Osteoporosis Reports·Beatriz Gámez, Claire M Edwards
Aug 22, 2018·Journal of Clinical Medicine·Caterina LeddaVenerando Rapisarda
Mar 31, 2020·Current Hematologic Malignancy Reports·Shivani SethPrashant Kapoor
Aug 30, 2006·British Journal of Haematology·Robert A Kyle, S Vincent Rajkumar
Oct 15, 2010·Proceedings·Robert Arthur Kyle, William Clifford Roberts
Apr 18, 2006·Current Treatment Options in Oncology·Joan Bladé, Laura Rosiñol
Jul 19, 2013·European Journal of Haematology·Silvia MangiacavalliAlessandro Corso
Jun 27, 2008·Advances in Anatomic Pathology·Saad P ShaheenL Jeffrey Medeiros
Jul 8, 2009·International Journal of Cancer. Journal International Du Cancer·Sigurdur Y KristinssonOla Landgren
Jan 9, 2013·British Journal of Haematology·Moshe E Gatt, Giovanni Palladini
Feb 24, 2011·European Journal of Haematology·Hlíf SteingrímsdóttirHelga M Ogmundsdóttir
Feb 4, 2014·Expert Review of Hematology·Rafael FonsecaMeletios A Dimopoulos
Jan 18, 2018·The New England Journal of Medicine·Robert A KyleS Vincent Rajkumar
May 29, 2010·British Journal of Haematology·James R BerensonRobert A Kyle
Aug 14, 2009·British Journal of Haematology·Jenny BirdUNKNOWN Haemato-oncology Task Force of the British Committee for Standards in Haematology, UK Myeloma Forum and Nordic Myeloma Study

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