PMID: 9189054May 1, 1997Paper

Long-term follow-up of 453 rheumatoid arthritis patients treated with methotrexate: an open, retrospective, observational study

British Journal of Rheumatology
C BolognaJ Sany

Abstract

A total of 453 rheumatoid arthritis (RA) patients were followed up for 35.2 +/- 27.9 months (range 3-106). The clinical parameters decreased significantly after 6 months. Twenty-eight patients were in remission (6.4%). Rheumatoid factor (RF) positivity was less common in the group of patients in remission, with a higher frequency of visits and methotrexate (MTX) onset after 65 yr. There was a significant degradation of radiographic lesions (n = 60). A total of 101 patients (23.1%) stopped MTX, for toxicity (n = 61) and failure (n = 20). The onset of MTX after 65 yr, a low number of visits and the occurrence of side-effects were predictive of MTX withdrawal. A total of 259 patients (59.3%) had side-effects. A Ritchie's index < or = 10, a lower polymorphonuclear cell count and the absence of RF were predictive of side-effects. The probability of being on MTX at 5 yr was 73%. This study confirms the high efficacy of MTX in RA.

Citations

Jul 6, 2000·Immunopharmacology·G S Alarcón
Nov 14, 2014·Immunologic Research·Vasco C RomãoJoão Eurico Fonseca
Aug 22, 2015·Journal of Crohn's & Colitis·Vito AnneseUNKNOWN ECCO
Aug 12, 2004·Seminars in Arthritis and Rheumatism·Andrea T BorchersM Eric Gershwin
Feb 13, 2002·Arthritis and Rheumatism·UNKNOWN American College of Rheumatology Subcommittee on Rheumatoid Arthritis Guidelines
Sep 8, 2005·Journal of Clinical Gastroenterology·John H Sun, Kiron M Das
Apr 7, 2007·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Haruko IdeguchiYoshiaki Ishigatsubo
May 26, 2005·Pharmacological Reviews·Bruce N Cronstein
Oct 8, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Dmitry A YarilinDavid N Posnett
Sep 1, 2018·International Journal of Rheumatic Diseases·Shuji AsaiToshihisa Kojima

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