Long-term follow-up of 76 Iranian patients with idiopathic inflammatory myopathies

International Journal of Rheumatic Diseases
Mehrzad HajialiloAida Malek Mahdavi

Abstract

This study aimed to follow up patients with polymyositis (PM) and/or dermatomyositis (DM) to determine survival rate, pattern of disease, response to treatment, malignancy incidence and poor prognostic factors (PPFs). A total of 76 patients with PM (n = 47) and/or DM (n = 29) based on Bohan and Peter diagnostic criteria referred to the Imam-Reza Hospital were followed up from 2004 to 2016. The follow-up period was considered from diagnosis to patient's death or last visit. All patients underwent physical examinations and data including age, sex, disease duration, disease subtype, pattern of disease, PPFs and malignancy incidence were collected. Mean age at diagnosis was 45.49 ± 10.88 years and women were predominant (84.2%). Course of disease in the majority of patients (52.6%) was polyphasic, followed by monophasic (31.6%) and chronic-progressive (5.3%). The 1-, 5- and 10-year survival rates were 96%, 93% and 92%, respectively. Delay in treatment and dysphagia were common PPFs in the present study. The majority of patients responded to treatment (88.2%) and there were significant differences in cancer and dysphagia between responders and non-responders to treatment (P < 0.05). The most common cause of death was cancer in four ...Continue Reading

References

Feb 13, 1975·The New England Journal of Medicine·A Bohan, J B Peter
May 8, 1998·Seminars in Arthritis and Rheumatism·C R MaozM Ehrenfeld
Apr 18, 2001·Dermatology : International Journal for Clinical and Investigative Dermatology·R E HungerC U Brand
Nov 28, 2002·International Journal of Dermatology·Nobuo WakataMasao Kinoshita
Jan 4, 2003·Rheumatic Diseases Clinics of North America·Frank L Mastaglia, Beverley A Phillips
Feb 16, 2006·Clinical Rheumatology·A AirioM Hakala
Apr 12, 2006·Annals of the Rheumatic Diseases·I M BronnerJ E Hoogendijk
Jun 14, 2006·Autoimmunity·Carmen TorresPatricia E Carreira
Dec 16, 2010·Neuropathology and Applied Neurobiology·M C Dalakas
Jun 18, 2011·Stroke; a Journal of Cerebral Circulation·Askiel BrunoFenwick T Nichols
Sep 13, 2014·Current Opinion in Rheumatology·Arash H LahoutiLisa Christopher-Stine
May 24, 2016·Clinical Rheumatology·Yao-Fan FangKuang-Hui Yu
Aug 18, 2016·Current Opinion in Rheumatology·Manabu FujimotoNaoko Okiyama
Aug 19, 2016·Journal of Cutaneous Medicine and Surgery·Judy K QiangRaed Alhusayen
Aug 20, 2016·Current Opinion in Rheumatology·Øyvind Molberg, Cecilie Dobloug
May 26, 2017·Zeitschrift für Rheumatologie·C FiehnT Dörner

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Citations

May 22, 2019·Rheumatology International·Alireza Khabbazi, Mohsen Soroosh

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