Long-Term Follow-Up of Adamantinoma of the Tibia Complicated by Metastases and a Second Unrelated Primary Cancer: A Case Report and Literature Review

Case Reports in Orthopedics
Brendan R SouthamSara Szabo

Abstract

Adamantinoma is a rare, low-grade malignant tumor of the bone which grows slowly and typically occurs in the diaphysis of long bones, particularly in the tibia. Adamantinomas have the potential for local recurrence and may metastasize to the lungs, lymph nodes, or bone. We report a case of a 14-year-old female with a tibial adamantinoma who underwent wide resection with limb salvage and has subsequently been followed up for 18 years. The patient went on to have both a local soft tissue recurrence 5 years after the resection and metastases to both an inguinal lymph node and the right lower lobe of the lung 8 years after that recurrence, all of which have been treated successfully with marginal resections. Unique to this case, the patient was also incidentally found to have chromophobe-type renal cell carcinoma when undergoing a partial nephrectomy to resect a presumed metastasis of her adamantinoma. Genetic testing has not revealed any known genetic predisposition to cancer.

References

Jul 1, 1991·Chest·J X Van SchoorM E Van Der Straeten
Jan 1, 1991·Skeletal Radiology·J W YoungN O Whitley
Jan 1, 1990·Acta Clinica Belgica·F De KeyserK P Van de Woestijne
Aug 1, 1989·Cancer·G L KeeneyD J Pritchard
Nov 1, 1974·Cancer·K K UnniJ C Ivins
Aug 23, 2000·The Journal of Bone and Joint Surgery. American Volume·A A QureshiS Gitelis
Jan 21, 2003·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Scott M LevineCatherine N Petchprapa
Mar 5, 2003·Clinical Orthopaedics and Related Research·Gary M ShermanYi Yang
Apr 8, 2003·Skeletal Radiology·Leonard B Kahn
Jul 17, 2003·Journal of Postgraduate Medicine·D K FilippouN T Demertzis
Apr 28, 2004·Seminars in Oncology·Andrea Luciani, Lodovico Balducci
Nov 18, 2004·AJR. American Journal of Roentgenology·Henk-Jan Van der WoudePancras C W Hogendoorn
Aug 17, 2005·International Journal of Dermatology·Michael Jude WelschMaria M Medenica
Mar 22, 2006·Journal of Surgical Oncology·Saral S DesaiNikhil Merchant
Aug 15, 2006·Pediatric Radiology·Rick Van RijnMario Maas
Mar 23, 2007·Orthopedics·Panayiotis J PapagelopoulosFranklin H Sim
Dec 7, 2007·Journal of Cancer Research and Clinical Oncology·Sönke P FreyGeorg Gosheger
Feb 19, 2008·Diagnostic Pathology·Deepali JainYashwant Kumar
Jan 1, 1997·Sarcoma·A N Van GeelM I Vermeulen
Jul 19, 2008·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Morgan D CampCharles H Bush
Oct 9, 2008·Journal of Pediatric Orthopedics. Part B·Vivek SharmaMargaret H Collins
Dec 3, 2008·Pathology Oncology Research : POR·Miklós SzendroiGabriella Arató
Sep 19, 2009·The Journal of International Medical Research·A F MavrogenisP J Papagelopoulos
Jun 1, 2010·The Journal of the American Academy of Orthopaedic Surgeons·Mathew J MostCarrie Y Inwards
Jun 22, 2012·International Journal of Urology : Official Journal of the Japanese Urological Association·Francisco Emilio Vera-BadilloIgnacio Duran
Jun 28, 2014·Orthopedics·Darlene M HoldenMurali Sundaram
Jan 1, 2015·Journal of Orthopaedic Surgery·D K GiannoulisT A Xenakis
Oct 1, 2015·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Ahmad Sukari HalimZulmi Wan
Sep 16, 2016·Case Reports in Oncological Medicine·Andrew D LimanRashmikant Shah
Oct 30, 2016·Orthopaedics & Traumatology, Surgery & Research : OTSR·S E PuchnerP T Funovics

❮ Previous
Next ❯

Citations

Apr 26, 2020·Journal of Surgical Oncology·Eugenia SchwarzkopfDaniel E Prince
Jun 5, 2021·BMJ Case Reports·Sarah SmythHooman Soleymani Majd

❮ Previous
Next ❯

Methods Mentioned

BETA
amputation
biopsy

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.