Long-term follow-up of bone density in women with primary ovarian insufficiency

Menopause : the Journal of the North American Menopause Society
Cristina Laguna Benetti-PintoDaniela A Yela

Abstract

This study aims to analyze long-term variation in bone mineral density among young women with primary ovarian insufficiency. A cohort study evaluated bone mineral density in 72 women with primary ovarian insufficiency who were receiving estrogen + progestogen therapy. Bone mineral density was evaluated every 2 years for 8 years. The women were young, with a mean (SD) age of 34.1 (6.7) years and had a bone density measurement at baseline. The mean (SD) time between the last menstruation and the beginning of hormone treatment was 2.9 (4.2) years. The initial mean (SD) bone mineral density was 1.03 (0.17) and 0.91 (0.16) g/cm for the lumbar spine and femoral neck, respectively. The mean (SD) T score was -1.03 (1.39) and -0.29 (1.09) for the lumbar spine and femoral neck, respectively. Bone mineral density measurements after a follow-up period of 2, 4, 6, and 8 years did not differ from bone mineral density at baseline. Osteopenia and osteoporosis were observed at the lumbar spine and femoral neck in 46% and 25% of women at the time of diagnosis, with no difference in the percentage of affected women across time. Although women with primary ovarian insufficiency who are receiving estrogen + progestogen therapy maintain stable bone ...Continue Reading

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Citations

Mar 31, 2016·Journal of Women's Health·Stephanie S FaubionWalter A Rocca
Jul 29, 2015·Menopause : the Journal of the North American Menopause Society·Luke A GattaPeter F Schnatz
Jun 3, 2016·Endocrinology, Diabetes & Metabolism Case Reports·Ana Marina Moreira, Poli Mara Spritzer
Jul 17, 2020·Climacteric : the Journal of the International Menopause Society·C LiJ Zhou
Jun 25, 2020·Menopause : the Journal of the North American Menopause Society·Lívia B Carvalho GazarraCristina Laguna Benetti-Pinto
Dec 3, 2016·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Helena GiraldoPaulo Giraldo

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