Long-Term Follow-Up of Cardiac Function and Quality of Life for Patients in NSABP Protocol B-31/NRG Oncology: A Randomized Trial Comparing the Safety and Efficacy of Doxorubicin and Cyclophosphamide (AC) Followed by Paclitaxel With AC Followed by Paclitaxel and Trastuzumab in Patients With Node-Positive Breast Cancer With Tumors Overexpressing Human Epidermal Growth Factor Receptor 2

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Patricia A GanzNorman Wolmark

Abstract

Purpose Early cardiac toxicity is a risk associated with adjuvant chemotherapy plus trastuzumab. However, objective measures of cardiac function and health-related quality of life are lacking in long-term follow-up of patients who remain cancer free after completion of adjuvant treatment. Patients and Methods Patients in NSABP Protocol B-31 received anthracycline and taxane chemotherapy with or without trastuzumab for adjuvant treatment of node-positive, human epidermal growth factor receptor 2-positive early-stage breast cancer. A long-term follow-up assessment was undertaken for patients who were alive and disease free, which included measurement of left ventricular ejection fraction by multigated acquisition scan along with patient-reported outcomes using the Duke Activity Status Index (DASI), the Medical Outcomes Study questionnaire, and a review of current medications and comorbid conditions. Results At a median follow-up of 8.8 years among eligible participants, five (4.5%) of 110 in the control group and 10 (3.4%) of 297 in the trastuzumab group had a > 10% decline in left ventricular ejection fraction from baseline to a value < 50%. Lower DASI scores correlated with age and use of medications for hypertension, cardiac c...Continue Reading

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Citations

Jun 26, 2018·Current Heart Failure Reports·Zarina Sharalaya, Patrick Collier
Jul 4, 2018·Journal of Cellular Physiology·Hui SunXianzhong Xiao
Sep 1, 2018·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Chau T DangRichard Steingart
Sep 11, 2018·Expert Opinion on Investigational Drugs·Enrique Soto-Perez-De-CelisArti Hurria
Oct 7, 2018·Cancer·Sonia PernasSara M Tolaney
Oct 17, 2018·Current Opinion in Oncology·Maria Vittoria DieciValentina Guarneri
Feb 20, 2019·Journal of Clinical Medicine·Marco MazzottaPatrizia Vici
Jul 11, 2019·The Journal of Physiology·Fabian Philipp KreutzerThomas Thum
Apr 29, 2020·Journal of the National Cancer Institute·Moira RushtonSusan Dent
Aug 14, 2020·Technology in Cancer Research & Treatment·Jun ShenShufang Hu
Apr 4, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Matthias PinterRakesh K Jain
Apr 1, 2021·Molecular Cancer Therapeutics·Li WanCarola A Neumann

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