Long-term follow-up of children treated for high-grade gliomas: children's oncology group L991 final study report.

Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology
Stephen A SandsJonathan L Finlay

Abstract

High-grade gliomas of the CNS are characterized by poor treatment response and prognosis for long-term survival. The Children's Oncology Group (COG) L991 study investigated the neuropsychological, behavioral, and quality of life (QoL) outcomes after treatment on the Children's Cancer Group (CCG) trial for high-grade gliomas (CCG-945). Fifty-four patients (29 males, 25 females) with a median age of 8.8 years at diagnosis (range, 0.2 to 19.5 years) were enrolled at 25 institutions in North America, representing 81% of available survivors; median length of follow-up was 15.1 years (range, 9.5 to 19.2 years), and median age at study evaluation was 23.6 years (range, 11.3 to 36 years). Standardized tests of neuropsychological functioning and QoL were performed. Descriptive statistics summarized principal findings, and one-way analysis of variance identified potential predictors of outcomes. With an average follow-up time of 15 years, survivors demonstrated intellectual functioning within the low-average range. Executive functioning and verbal memory were between the low-average and borderline ranges. In contrast, visual memory and psychomotor processing speed were between the borderline and impaired ranges, respectively. Approximate...Continue Reading

References

Sep 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J H SilberA T Meadows
May 1, 1992·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·D P WaberS E Sallan
Jan 1, 1991·Archives of Disease in Childhood·C Eiser
Mar 1, 1990·Developmental Medicine and Child Neurology·D P WaberS E Sallan
Apr 1, 1989·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·D RivaF Fossati Belani
Nov 9, 1994·JAMA : the Journal of the American Medical Association·R HauptJ Byrne
Jun 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·J RadcliffeP C Phillips
Feb 1, 1994·Journal of Clinical and Experimental Neuropsychology·M D Ris, R B Noll
Jul 11, 1998·Medical and Pediatric Oncology·M DennisB J Spiegler
Dec 22, 1999·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·J L Finlay, J H Wisoff
Apr 18, 2001·Current Opinion in Oncology·J G Gurney, N Kadan-Lottick
Aug 2, 2001·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·M D RisJ M Boyett
Feb 8, 2002·The New England Journal of Medicine·Ian F PollackUNKNOWN Children's Cancer Group
Dec 14, 2002·Annals of the New York Academy of Sciences·John T O'BrienGary A Ford
Aug 30, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Roger J PackerLeslie L Robison
Dec 3, 2003·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Dorie A GloverUNKNOWN Children's Cancer Group
Mar 12, 2004·Journal of the International Neuropsychological Society : JINS·Raymond K MulhernWilburn E Reddick
Jul 3, 2004·The Lancet Oncology·Raymond K MulhernLarry E Kun
Jul 20, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Ian F PollackJonathan L Finlay
Oct 25, 2006·Mental Retardation and Developmental Disabilities Research Reviews·Robert W Butler, Jennifer K Haser
Jan 11, 2007·Archives of Neurology·Mahlon R DeLong, Thomas Wichmann
Oct 2, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Gregory T ArmstrongLeslie L Robison
Oct 13, 2007·Developmental Neuropsychology·Robyn StargattDavid Ashley
Mar 12, 2008·Neuropsychology·Donald J MabbottEric Bouffet
Sep 12, 2008·AJNR. American Journal of Neuroradiology·W LinJ H Gilmore
Dec 6, 2008·The Cerebellum·Maja Steinlin
Feb 11, 2009·Journal of the International Neuropsychological Society : JINS·Donald J MabbottAdrienne Witol
Jul 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christophe HabasMichael D Greicius
Oct 7, 2009·Brain : a Journal of Neurology·E Brannon MorrisRobert J Ogg

❮ Previous
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Citations

Feb 27, 2013·Current Treatment Options in Neurology·Jane E Minturn, Michael J Fisher
Mar 26, 2013·Journal of Neuro-oncology·Heather M ConklinShengjie Wu
Jul 12, 2014·Clinical Neurology and Neurosurgery·Caroline UnsinnOliver Bozinov
Jun 14, 2015·Child Neuropsychology : a Journal on Normal and Abnormal Development in Childhood and Adolescence·Katie Olson, Stephen A Sands
Mar 3, 2015·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Sumedh Subodh ShahMohamed Samy Elhammady
Jun 18, 2016·Supportive Care in Cancer : Official Journal of the Multinational Association of Supportive Care in Cancer·Alice EmondMichael Evangeli
Jun 24, 2016·Pediatric Hematology and Oncology·Arianne B DessensCoriene E Catsman-Berrevoets
Dec 21, 2012·Pediatric Blood & Cancer·Lillian SungUNKNOWN Children's Oncology Group Cancer Control and Supportive Care Committee
Sep 12, 2012·Nature Reviews. Neurology·Laetitia PadovaniXavier Muracciole
Dec 21, 2012·Pediatric Blood & Cancer·Saro H ArmenianUNKNOWN COG Survivorship and Outcomes Committee
Nov 28, 2013·International Journal of Rheumatology·Francesco CasoLuca Cantarini
Aug 8, 2018·BMC Health Services Research·Bjørg Eva SkogøyTerje Ogden
Oct 31, 2019·Child Development·Christina WeilandEleanor Martin
Sep 28, 2017·NeuroRehabilitation·J C Arango-LasprillaN Albaladejo-Blázquez
Aug 24, 2013·Mediators of Inflammation·Antonio VitaleLuca Cantarini
Jan 13, 2018·Expert Review of Neurotherapeutics·Nicole A P LiebermanCourtney A Crane

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