Long-term follow-up of circulating oxidative stress markers in patients undergoing lipoprotein apheresis by Direct Adsorption of Lipids (DALI)

Atherosclerosis. Supplements
Steffi KoppraschUlrich Julius

Abstract

Beyond its well-established efficacy in lowering atherogenic lipids and lipoproteins, DALI (Direct Adsorption of Lipids) apheresis has been shown to have acute anti-inflammatory and endothelium-protective effects. In the present study, we investigated long-term effects of DALI procedures on circulating oxidative stress markers. Thirteen patients involved in the study underwent regular DALI apheresis for nearly two years. At sessions 1, 40 and 80 conventional lipid status and changes of systemic oxidative stress markers (oxidized LDL, anti-oxidized LDL antibodies, advanced oxidation protein products (AOPP), and myeloperoxidase (MPO)) were examined. DALI procedure efficiently reduced atherogenic lipids/lipoproteins. On day three after apheresis lipid parameters returned to pre-apheresis values. They showed no tendency to increase or to decrease over time. No significant differences were found between 1st, 40th and 80th sessions. In a similar way, levels of oxidative stress biomarkers acutely decreased after apheresis sessions and rebounded on day three after apheresis. No significant differences were observed between sessions 1, 40, and 80. DALI apheresis repeatedly decreases atherogenic lipid/lipoprotein profile and oxidative st...Continue Reading

Citations

Oct 9, 2019·Molecular Psychiatry·Stefan R BornsteinRichard Straube
Nov 30, 2019·Journal of Clinical Apheresis·Randolf HardersenAnders Hovland
Aug 25, 2020·Oxidative Medicine and Cellular Longevity·Agnieszka MickiewiczMaciej Jankowski

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