PMID: 2114241May 1, 1990Paper

Long-term follow-up of 'cured' prolactinoma patients after successful adenomectomy

Clinical Endocrinology
E CiccarelliF Camanni

Abstract

The long-term follow-up (greater than or equal to 4 years) of clinical, hormonal and radiological aspects in 22 'cured' prolactinoma patients after adenomectomy was studied. Dynamic secretion of PRL and TSH was also evaluated, in order to identify the persistence of any underlying abnormality of hypothalamic pituitary control and to predict relapses. A relapse into hyperprolactinaemia was shown in 36% of patients 5-90 months (mean 46) after surgery. This was accompanied by reappearance of clinical symptoms but not by the radiological demonstration of the adenoma in any patients. A significant PRL rise after domperidone, a dopaminergic antagonist drug, was shown in cured patients after surgery (mean +/- SEM peak, 2977 +/- 645 mU/l) but this was markedly lower than that observed in control subjects (5732 +/- 440 mU/l). In fact, normal PRL increments were shown in only 6/16 (37%) patients. TSH hyper-responsiveness to domperidone normalized in only 46% of patients. Similar PRL responses to those obtained with domperidone were shown when a TRH test was given. A relapse into hyperprolactinaemia was observed in six of ten (60%) non-responders to domperidone and in four of seven (57%) non-responders to TRH, whereas six normal responder...Continue Reading

References

Jun 2, 1979·Lancet·E A CowdenG M Teasdale
Mar 1, 1978·The Journal of Clinical Endocrinology and Metabolism·P JaquetP Carayon
Jun 1, 1986·The Journal of Clinical Endocrinology and Metabolism·J A SchlechteJ VanGilder
Nov 30, 1985·British Medical Journal·M F ScanlonR Hall
Nov 30, 1985·British Medical Journal·J A ThomsonD L Davies
May 1, 1985·The Journal of Clinical Endocrinology and Metabolism·T L MartinW B Malarkey
Dec 1, 1983·The Journal of Clinical Endocrinology and Metabolism·F CamanniE E Müller
Jul 1, 1982·Acta Endocrinologica·H K RjoskK von Werder
Apr 1, 1981·American Journal of Obstetrics and Gynecology·C M MarchD R Mishell
Sep 1, 1980·The Journal of Clinical Endocrinology and Metabolism·F CamanniE E Müller

❮ Previous
Next ❯

Citations

Oct 30, 2016·Journal of Neurosurgery·Hazem M NegmTheodore H Schwartz
Feb 1, 1992·Clinical Endocrinology·C W Burke
May 18, 2006·Endocrine Reviews·Mary P GillamAnnamaria Colao
Feb 9, 2016·Expert Opinion on Drug Safety·Renata S AuriemmaAnnamaria Colao
Sep 1, 1992·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·U M FahyM G Hull
Feb 13, 2001·Acta Obstetricia Et Gynecologica Scandinavica·P TouraineF Kuttenn

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.