Long-term follow-up of femoral shaft fracture: Relevance of malunion and malalignment for the development of knee arthritis

Injury
J R A PhillipsT R C Davis

Abstract

It has not yet been well established whether femoral shaft fracture malunion and malalignment lead to the development of knee osteoarthritis.This study has assessed a cohort of 62 patients after femoral shaft fracture at a median follow-up of 22 years (range 18–28). The mean age of the patients at time of follow-up was 42 years (33–80). Each patient was clinically examined for signs and symptoms of osteoarthritis, radiographs were taken to assess malalignment and radiographic osteoarthritic changes, and WOMAC and SF-36 (physical and mental) scores were measured.Radiographic changes consistent with osteoarthritis were present in only 5 (8%) ipsilateral and 3 (5%)contralateral knees. Clinical signs and symptoms of osteoarthritis were present in only two (3%)ipsilateral knees. However, 16 patients (26%) exhibited mild pain or stiffness in the ipsilateral knee,while only 4 patients (6%) had such findings in their ipsilateral knee (OR 4; p = 0.004).The median WOMAC score for knee pain was 3 (range 1–15; max 20), knee stiffness was 1 (0–8; max 8) and disability was 6 (0–55; max 68). The median SF-36 score for physical function was 85 (range 0–100; max 100).The mean coronal plane malunion was 58 (range 198 to 88). There was no signifi...Continue Reading

References

Jan 1, 1991·Journal of Orthopaedic Trauma·R M PunoJ R Johnson
Apr 1, 1989·Acta Orthopaedica Scandinavica·K D KristensenJ Blicher
Dec 11, 1997·The Journal of Bone and Joint Surgery. British Volume·S A Milner
Jul 13, 2001·JAMA : the Journal of the American Medical Association·L SharmaD D Dunlop
Jun 14, 2002·The Journal of Bone and Joint Surgery. American Volume·S A MilnerM Doherty
Oct 3, 2002·The Journal of Bone and Joint Surgery. British Volume·E García-CimbreloR Marti-Ciruelos
Mar 30, 2007·Arthritis and Rheumatism·David J HunterYuqing Zhang

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Citations

Jan 10, 2019·The Journal of the American Academy of Orthopaedic Surgeons·Peter K SculcoS Robert Rozbruch
Jul 14, 2020·Journal of Orthopaedic Trauma·Michael G SchlossRobert V O'Toole

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