Long-term follow up of initial clinical cases with NF-kappaB decoy oligodeoxynucleotide transfection at the site of coronary stenting

The Journal of Gene Medicine
Kensuke EgashiraRyuichi Morishita

Abstract

An essential transcription factor for inflammation, nuclear factor-kappa B (NF-kappaB), plays a pivotal role for restenosis after percutaneous coronary intervention (PCI). To evaluate the safety and effectiveness of NF-kappaB decoy oligodeoxynucleotides (ODN) to prevent restenosis, we initiated an open-label phase I/IIa clinical trial. Seventeen patients who were suffering from angina with organic coronary stenosis were treated with NF-kappaB decoy ODN after PCI using bare metal stents. Although the average coronary stenosis was 90.8 +/- 7.0% before the stent implantation, the stenosis improved to 1.4 +/- 5.9% after the intervention. Serum MCP-1 levels were significantly suppressed in NF-kappaB decoy ODN treated patients compared to those in non-treated patients on day 3 after the PCI. Ticlopidine treatment was employed, since clopidogrel was not launched in Japan. Six months after the PCI and decoy ODN transfection, significant restenosis was found in only 1 of the 17 patients, and the average restenosis rate was 39.6 +/- 22.3%. No in-stent thrombosis was found and no significant systemic adverse effect occurred in any of the patients in this observation period. These results suggest the clinical usefulness and safety of the N...Continue Reading

References

Jun 11, 2002·Journal of Interventional Cardiology·H Störger
Dec 25, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Ryuichi Morishita
Mar 12, 2003·Circulation·Michael HaudeUNKNOWN Heparin-COAted STents in small coronary arteries Trial Investigators
Jun 10, 2006·Journal of Molecular and Cellular Cardiology·Takashi MiyakeRyuichi Morishita
Feb 16, 2007·Journal of Interventional Cardiology·Martin B Leon
Apr 25, 2007·American Heart Journal·Vincenzo PasceriGermano Di Sciascio
Sep 22, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Kensuke EgashiraKenji Sunagawa

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Citations

Apr 18, 2013·American Journal of Respiratory Cell and Molecular Biology·Daniela De StefanoRaffaella Sorrentino
Jul 31, 2013·Heart Failure Reviews·Chuichi Kawai, Akira Matsumori
Oct 25, 2011·Expert Opinion on Therapeutic Patents·Roberto Gambari
Mar 5, 2016·Nucleic Acids Research·Miriam KlausRalf Jauch
Dec 12, 2012·The Journal of Investigative Dermatology·Hong-Feng YuanXiang Xu
Nov 4, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Haiying HuangHiroyuki Mizuguchi
Jul 2, 2009·Journal of Thrombosis and Haemostasis : JTH·E MalaverM Schattner
Apr 15, 2016·Blood Reviews·Eduardo FuentesIván Palomo
Feb 24, 2010·Clinical Science·Kim Van der HeidenPaul C Evans
Jun 12, 2010·European Journal of Vascular and Endovascular Surgery : the Official Journal of the European Society for Vascular Surgery·M PeroulisA Macheras
Jan 14, 2010·Journal of Biomedicine & Biotechnology·Jun-ichi SuzukiRyozo Nagai
Jun 3, 2016·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Levon M Khachigian
Jun 24, 2017·Biochemical Pharmacology·Markus Hecker, Andreas H Wagner
Jul 24, 2010·Journal of the American Society of Nephrology : JASN·Ana Belen SanzAlberto Ortiz
Jun 13, 2012·International Heart Journal·Rikuta HamayaMitsuaki Isobe
Nov 26, 2015·Journal of Biomolecular Screening·Felicity D HerringtonCarl S Goodyear
Jul 6, 2019·Annals of Vascular Diseases·Takashi MiyakeRyuichi Morishita
Dec 17, 2009·Circulation Journal : Official Journal of the Japanese Circulation Society·Jun-ichi SuzukiRyozo Nagai
Apr 10, 2021·Cell Chemical Biology·Kusal T G SamarasingheCraig M Crews

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