Long-term follow-up of intensive ara-C-based chemotherapy followed by bone marrow transplantation for adult acute lymphoblastic leukemia: impact of induction Ara-C dose and post-remission therapy

Leukemia Research
E M SotomayorS D Gore

Abstract

We report single institution outcome of brief, intensive ara-C-based chemotherapy using bone marrow transplantation as primary intensification for untreated adult patients with acute lymphoblastic leukemia (ALL). Overall disease-free and overall survival were inferior to those reported with prolonged chemotherapy modeled on pediatric protocols. Survival and disease-free survival were superior for patients receiving allogeneic BMT compared with chemopurged autologous transplant or maintenance chemotherapy (patients ineligible for or declining BMT). In multivariate analysis, non-L2-FAB, higher ara-C dose, absence of CNS disease, non-Ph1+ karyotype, allogeneic BMT, T cell phenotype, and younger age were associated with improved disease-free survival. Autologous BMT was not superior to chemotherapy, and appears unlikely to provide adequate curative treatment for most adult ALL patients if not followed by maintenance.

References

May 1, 1992·Leukemia & Lymphoma·P Ljungman, G Gahrton
Jan 1, 1993·Journal of Hematotherapy·C I Civin, S D Gore
Oct 28, 1993·The New England Journal of Medicine·G K RiveraW M Crist

❮ Previous
Next ❯

Citations

Sep 21, 2000·Critical Reviews in Oncology/hematology·N SabaA Keating
Jun 12, 2003·Current Opinion in Hematology·Partow Kebriaei, Richard A Larson
Jun 9, 2004·Critical Reviews in Oncology/hematology·Renato BassanRoel Willemze
Jan 10, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Theresa HahnPhilip L McCarthy
Oct 3, 2008·Cancer Letters·Xiao-shan LiuYing-mu Cai
Aug 22, 2006·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Ivan AksentijevichIan W Flinn
Nov 19, 2009·Biochemical and Biophysical Research Communications·Shogo KojimaKeizo Takenaga
Jun 5, 2003·Expert Review of Molecular Diagnostics·Beate Gleissner, Eckhard Thiel

❮ Previous
Next ❯

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.