Long-term follow-up of nailfold videocapillaroscopic changes in dermatomyositis versus systemic sclerosis patients

Clinical Rheumatology
Carmen PizzorniSabrina Paolino

Abstract

To identify nailfold videocapillaroscopy (NVC) changes in patients with dermatomyositis (DM) during a 3-year follow-up and to compare the NVC findings between DM and systemic sclerosis (SSc) patients at their first visit. Retrospective study of 24 DM and 24 SSc patients, matched for age and disease duration at first NVC. Capillaroscopic patterns/scores and clinical parameters had been yearly assessed. Nineteen out of 24 DM patients (79%) showed a NVC "scleroderma-like pattern." No statistically significant variation of all the capillaroscopic scores was observed during the 3-year follow-up. By comparing DM patients with or without anti-Jo-1 positivity, no statistically significant difference of the scores of the main capillary parameters was observed at baseline between the groups. Comparing at baseline DM with SSc patients, the giant capillary and microhemorrhage scores were significantly higher in SSc than those in DM patients (p = 0.04 and p = 0.05, respectively), while capillary density, ramification (abnormally shaped capillaries, expression of angiogenesis), and disorganization scores were higher in DM patients (p = 0.05, p = 0.002, p = 0.004, respectively). The absolute number of ramified capillaries was significantly hi...Continue Reading

References

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Sep 27, 2003·Lancet·Marinos C Dalakas, Reinhard Hohlfeld
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Citations

Aug 10, 2019·Clinical Rheumatology·Maurizio CutoloVanessa Smith
Mar 23, 2021·Dermatologic Clinics·Florence Dehavay, Bertrand Richert
Jun 29, 2021·Arthritis Research & Therapy·Giorgia FerrariMaurizio Cutolo
Sep 26, 2021·Nature Reviews. Rheumatology·Maurizio Cutolo, Vanessa Smith

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