PMID: 11903281Mar 21, 2002Paper

Long-term follow-up of patients treated for chronic headache with analgesic overuse

Cephalalgia : an International Journal of Headache
L A PiniM Sandrini

Abstract

The study aim is to describe the long-term clinical outcome of 102 chronic headache patients with analgesic daily use. They were assessed for daily drug intake (DDI), headache index (HI) and quality of life (QoL) and compared with a parallel group of patients with active chronic daily headache but no analgesic overuse. For the primary study group, baseline 1995 DDI was 1.80 +/- 1.87 and did not differ significantly in 1999. Patients who daily continued to use analgesics had a higher 1995 baseline DDI (t = 2.275, P = 0.025), a longer drug abuse history (t = 2.282, P = 0.025) and a higher DDI (t = 4.042, P < 0.001) 4 years later. At 4 years of follow-up, only one-third of patients initially treated for chronic daily headache and analgesic overuse are successful in refraining from chronic overuse. Those subjects appear to have a persistence for combination analgesic agents; however, their QoL is slightly better than that of patients who revert to episodic headache or continue with chronic daily headache but do not overuse analgesic agents. Persistent analgesic overuse seems to be linked to the length of abuse and to the number of drugs ingested.

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Citations

Jul 9, 2002·Cephalalgia : an International Journal of Headache·M E BigalS J Tepper
Dec 21, 2004·Cephalalgia : an International Journal of Headache·Z KatsaravaV Limmroth
Dec 31, 2004·Current Pain and Headache Reports·William Pryse-Phillips
Jan 13, 2006·The New England Journal of Medicine·David W Dodick
Oct 17, 2006·Headache·Marcelo E Bigal, Richard B Lipton
Oct 6, 2009·The Journal of Headache and Pain·Paolo RossiUNKNOWN COMOESTAS Consortium
Jun 28, 2011·Cephalalgia : an International Journal of Headache·C Créac'hM Navez
Apr 18, 2013·Current Opinion in Neurology·Zaza Katsarava, Mark Obermann
Nov 5, 2002·Current Pain and Headache Reports·Vincenzo Guidetti, Federica Galli
Sep 27, 2003·Cephalalgia : an International Journal of Headache·M SilvestriniL Provinciali
Dec 7, 2005·Brain : a Journal of Neurology·Arnaud FumalJean Schoenen
Mar 8, 2008·Current Treatment Options in Neurology·Sait AshinaMarcelo E Bigal
Dec 24, 2005·Expert Opinion on Drug Safety·Mark ObermannZaza Katsarava
Sep 18, 2007·Expert Review of Neurotherapeutics·Mark Obermann, Zaza Katsarava
Aug 8, 2007·Cephalalgia : an International Journal of Headache·N ImaiT Okabe
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Aug 9, 2003·Expert Opinion on Drug Safety·Guenther Fritsche, Hans-Christoph Diener
May 15, 2007·Current Opinion in Neurology·Zaza Katsarava, Rigmor Jensen
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Dec 13, 2016·Cephalalgia : an International Journal of Headache·Jasna J Zidverc-TrajkovicNadezda Sternic

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