Long-term follow-up of patients undergoing autologous noncultured melanocyte-keratinocyte transplantation for vitiligo and other leukodermas

Journal of the American Academy of Dermatology
Narumol Silpa-ArchaIltefat H Hamzavi

Abstract

Persistence of pigmentation after a melanocyte-keratinocyte transplantation procedure (MKTP) is an important consideration for efficacy. We sought to determine long-term repigmentation of MKTP in vitiligo and other leukodermas. A retrospective review of electronic medical records was conducted for all MKTPs performed at Henry Ford Hospital between January 2009 and April 2014. Repigmentation was assessed by a 5-point grading scale (poor to excellent) and Vitiligo Area Scoring Index (VASI). One hundred patients had MKTP performed at 236 anatomically-based lesions (ABLs); 63 patients with 157 ABLs had long-term data available (12-72 months; median, 24 months). Segmental vitiligo, nonsegmental vitiligo, and physical leukoderma demonstrated improvement in VASI scores: -75.6 ± 24.6%, -59.2 ± 36.6%, and -32.4 ± 33.5%, respectively. In vitiligo, at 24, 48, and 72 months after MKTP, 53%, 64%, and 53% of ABLs, respectively, maintained >75% repigmentation. Skin phototype, age, and anatomic location of ABLs had no significant effect on the outcome of treatment. Limitations of the study include the retrospective design with uncontrolled, postoperative adjuvant treatments and inconsistent compliance to scheduled follow-up evaluations. MKTP p...Continue Reading

Citations

Feb 22, 2018·Plastic and Reconstructive Surgery. Global Open·Bonnie C CarneyJeffrey W Shupp
Aug 18, 2018·Pigment Cell & Melanoma Research·Jung Min BaeUNKNOWN East Asia Vitiligo Association
Feb 23, 2019·Journal of the European Academy of Dermatology and Venereology : JEADV·S AltalhabK Ezzedine
Aug 10, 2019·Indian Journal of Dermatology, Venereology and Leprology·Hai-Xia ShiLi Xiao
Jul 10, 2020·The Journal of Dermatological Treatment·Thanyanan SritanyaratNarumol Silpa-Archa
Jul 26, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Alexis B LyonsIltefat H Hamzavi
Feb 6, 2020·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Hoda M RasheedNesrin S Elkhouly

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