Long-term follow-up of surgically treated juvenile patients with Moyamoya disease

Journal of Neurosurgery. Pediatrics
Maki MukawaKikuo Ohno

Abstract

Surgical revascularization is considered an effective treatment for juvenile patients with moyamoya disease (MMD). Yet the long-term outcome in surgically treated patients still needs to be clarified. More than 30 years have passed since the authors' department started intensively treating pediatric patients with MMD using indirect anastomosis techniques. In this study the authors surveyed the current status of these patients. Activities of daily living (ADLs) were surveyed and present clinical status was assessed based on the modified Rankin scale (mRS). Cerebrovascular events subsequent to surgical treatment were also recorded. Since 1979, 208 patients younger than 19 years of age with MMD were surgically treated and followed up for > 3 years. Data were available on 172 patients (83%), who had been followed up for a mean of 14.3 years (range 3-32 years). Activity of daily living outcomes were as follows: 138 patients (80.2%) had mRS scores of 0-2, 29 (16.9%) a score of 3, 1 (0.6%) a score of 4, 1 (0.6%) a score of 5, and 3 (1.7%) a score of 6. Cerebrovascular events occurred 8 or more years after surgery in 6 patients (3.4%), that is, 6 hemorrhages and 3 infarctions. The cumulative risk of late-onset stroke at 10, 20, and 30 ...Continue Reading

References

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Citations

Oct 22, 2013·Journal of Neurosurgery. Pediatrics·Takeshi FunakiSusumu Miyamoto
Dec 7, 2013·Current Neurology and Neuroscience Reports·Annick KronenburgCatharina J M Klijn
Jan 11, 2014·Journal of Physical Therapy Science·Ki Seok Nam
Aug 18, 2018·Journal of Neurosurgery. Pediatrics·Nisha GadgilRobert C Dauser
Mar 6, 2019·Journal of Neurosurgery. Pediatrics·Coleman P RiordanR Michael Scott
Jun 27, 2019·Neurology·Dominique HervéHugues Chabriat
Oct 13, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Jiro Aoyama Taketoshi Maehara
May 12, 2021·Stroke; a Journal of Cerebral Circulation·Toshiaki HayashiTeiji Tominaga
Jun 12, 2021·Journal of Neurosurgery. Pediatrics·Madeline B KarstenR Michael Scott

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