Long-term follow-up of surgically treated juvenile patients with Moyamoya disease

Journal of Neurosurgery. Pediatrics
Maki MukawaKikuo Ohno


Surgical revascularization is considered an effective treatment for juvenile patients with moyamoya disease (MMD). Yet the long-term outcome in surgically treated patients still needs to be clarified. More than 30 years have passed since the authors' department started intensively treating pediatric patients with MMD using indirect anastomosis techniques. In this study the authors surveyed the current status of these patients. Activities of daily living (ADLs) were surveyed and present clinical status was assessed based on the modified Rankin scale (mRS). Cerebrovascular events subsequent to surgical treatment were also recorded. Since 1979, 208 patients younger than 19 years of age with MMD were surgically treated and followed up for > 3 years. Data were available on 172 patients (83%), who had been followed up for a mean of 14.3 years (range 3-32 years). Activity of daily living outcomes were as follows: 138 patients (80.2%) had mRS scores of 0-2, 29 (16.9%) a score of 3, 1 (0.6%) a score of 4, 1 (0.6%) a score of 5, and 3 (1.7%) a score of 6. Cerebrovascular events occurred 8 or more years after surgery in 6 patients (3.4%), that is, 6 hemorrhages and 3 infarctions. The cumulative risk of late-onset stroke at 10, 20, and 30 ...Continue Reading


Jan 1, 1977·Neurologia Medico-chirurgica·J KarasawaY Yoshida
Nov 1, 1978·Journal of Neurosurgery·J KarasawaT Sakaki
May 1, 1988·Stroke; a Journal of Cerebral Circulation·J C van SwietenJ van Gijn
May 1, 1994·Stroke; a Journal of Cerebral Circulation·T NariaiM Senda
Oct 1, 1995·Biopharmaceutics & Drug Disposition·T Cercós-ForteaM Merino
Feb 1, 1997·Surgical Neurology·M Fukui
Nov 1, 1996·Neurologia Medico-chirurgica·K HoukinH Abe
Mar 8, 2000·Neuropediatrics·C ImaizumiM Takeshita
Jan 31, 2002·Pediatric Neurosurgery·Mitsuo IsonoHidenori Kobayashi
May 14, 2003·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·Chae-Yong KimByung-Kyu Cho
Apr 19, 2005·Journal of Neurology, Neurosurgery, and Psychiatry·T NariaiK Ohno
Jul 29, 2005·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Yoji TanakaKikuo Ohno
Nov 1, 2005·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·B Darwish, M Besser

❮ Previous
Next ❯


Oct 22, 2013·Journal of Neurosurgery. Pediatrics·Takeshi FunakiSusumu Miyamoto
Dec 7, 2013·Current Neurology and Neuroscience Reports·Annick KronenburgCatharina J M Klijn
Jan 11, 2014·Journal of Physical Therapy Science·Ki Seok Nam
Aug 18, 2018·Journal of Neurosurgery. Pediatrics·Nisha GadgilRobert C Dauser
Mar 6, 2019·Journal of Neurosurgery. Pediatrics·Coleman P RiordanR Michael Scott
Jun 27, 2019·Neurology·Dominique HervéHugues Chabriat
Oct 13, 2020·International Journal of Stroke : Official Journal of the International Stroke Society·Jiro Aoyama Taketoshi Maehara
May 12, 2021·Stroke; a Journal of Cerebral Circulation·Toshiaki HayashiTeiji Tominaga
Jun 12, 2021·Journal of Neurosurgery. Pediatrics·Madeline B KarstenR Michael Scott

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.