Long-term follow-up of the AVOD randomized trial of antibiotic avoidance in uncomplicated diverticulitis

The British Journal of Surgery
D IsacsonA Chabok

Abstract

The aim of this study was to assess the long-term results in patients with uncomplicated diverticulitis who had participated in the Antibiotics in Acute Uncomplicated Diverticulitis (AVOD) RCT, which randomized patients with CT-verified left-sided acute uncomplicated diverticulitis to management without or with antibiotics. The medical records of patients who had participated in the AVOD trial were reviewed for long-term results such as recurrences, complications and surgery. Quality-of-life questionnaires (EQ-5D™) were sent to patients, who were also contacted by telephone. Descriptive statistics were used for the analysis of clinical outcomes. A total of 556 of the 623 patients (89·2 per cent) were followed up for a median of 11 years. There were no differences between the no-antibiotic and antibiotic group in recurrences (both 31·3 per cent; P = 0·986), complications (4·4 versus 5·0 per cent; P = 0·737), surgery for diverticulitis (6·2 versus 7·1 per cent; P = 0·719) or colorectal cancer (0·4 versus 2·1 per cent; P = 0·061). The response rate for the EQ-5D™ was 52·8 versus 45·2 per cent respectively (P = 0·030), and no differences were found between the two groups in any of the measured dimensions. Antibiotic avoidance for u...Continue Reading

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Citations

May 10, 2020·Diseases of the Colon and Rectum·Jason HallUNKNOWN Prepared on behalf of the Clinical Practice Guidelines Committee of the American Society of Colon and Rectal Surgeons
Dec 24, 2019·The British Journal of Surgery·R C Grossman
Jul 9, 2020·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·J K SchultzE Angenete
Nov 21, 2019·The British Journal of Surgery·G Pellino
Oct 3, 2019·The British Journal of Surgery·R C Grossman
Apr 3, 2020·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Rebekah JaungIan Bissett
Jan 21, 2021·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·Andrew S MillerDanette Wright
Nov 7, 2020·International Journal of Colorectal Disease·Alexandra M Zaborowski, Des C Winter
Mar 18, 2021·World Journal of Gastroenterology : WJG·Mark H Hanna, Andreas M Kaiser
Nov 9, 2019·Journal of Visceral Surgery·K SlimL Beyer-Berjot
May 4, 2021·Scandinavian Journal of Surgery : SJS : Official Organ for the Finnish Surgical Society and the Scandinavian Surgical Society·A ChabokV Sallinen
May 3, 2021·Current Problems in Surgery·Jordan M RookMary R Kwaan

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