Long-term follow-up of topical 5-aminolaevulinic acid photodynamic therapy diode laser single session for non-melanoma skin cancer

Photodiagnosis and Photodynamic Therapy
C S SouzaV S Bagnato

Abstract

Photodynamic therapy (PDT) is based on the association of a light source and light sensitive agents in order to cause the selective death of tumor cells. To evaluate topical 5-aminolaevulinic acid (5-ALA) and diode laser photodynamic single session therapy single session for non-melanoma skin cancer (NMSC), a long-term follow-up was performed. Nineteen Bowen's disease (BD) and 15 basal cell carcinoma (BCC) lesions were submitted to 6-h topical and occlusive 20% 5-ALA plus DMSO and EDTA, and later were exposed to 630 nm diode laser, 100 or 300 J cm(-2) dose. At 3 months tumor-free rate was 91.2% (31/34) whereas at 60 months, 57.7% (15/26), slightly higher in BCC (63.6%; 7/11). The relation between the reduction of the clinical response and the increase of tumor dimension observed at 18 months was lost at 60 months. The sBCC recurrence was earlier compared to the nBCC one. ALA-PDT offered important advantages: it is minimally invasive, an option for patients under risk of surgical complications; clinical feasibility; treatment of multiple lesions in only one session or lesions in poor healing sites and superior esthetical results. However, the recurrence rate increase after ALA-PDT diode laser single session can be observed at lo...Continue Reading

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Citations

Apr 17, 2013·Wiener medizinische Wochenschrift·Uwe Wollina, Georgi Tchernev
Dec 1, 2005·Photodiagnosis and Photodynamic Therapy·V MadanE Allan
Mar 19, 2011·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Sonal ChoudharyKeyvan Nouri
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Mar 1, 2012·Photodiagnosis and Photodynamic Therapy·Xiaona ZhangLibo Li
Feb 11, 2014·Clinical Implant Dentistry and Related Research·Paulo Esteves Pinto FariaLuiz Antonio Salata
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